Adverts

Open Access Articles- Top Results for SOX8

SOX8

Template:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/row
Identifiers
SymbolsSOX8 ; MGC24837
External IDsOMIM605923 MGI98370 HomoloGene7950 GeneCards: SOX8 Gene
Orthologs
SpeciesHumanMouse
Entrez3081220681
EnsemblENSG00000005513ENSMUSG00000024176
UniProtP57073Q04886
RefSeq (mRNA)NM_014587NM_011447
RefSeq (protein)NP_055402NP_035577
Location (UCSC)Chr 16:
1.03 – 1.04 Mb
Chr 17:
25.57 – 25.57 Mb
PubMed search[1][2]

Transcription factor SOX-8 is a protein that in humans is encoded by the SOX8 gene.[1][2][3]

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein may be involved in brain development and function. Haploinsufficiency for this protein may contribute to the mental retardation found in haemoglobin H-related mental retardation (ATR-16 syndrome).[3]

See also

References

  1. ^ Pfeifer D, Poulat F, Holinski-Feder E, Kooy F, Scherer G (Apr 2000). "The SOX8 gene is located within 700 kb of the tip of chromosome 16p and is deleted in a patient with ATR-16 syndrome". Genomics 63 (1): 108–16. PMID 10662550. doi:10.1006/geno.1999.6060. 
  2. ^ Schepers GE, Bullejos M, Hosking BM, Koopman P (Apr 2000). "Cloning and characterisation of the Sry-related transcription factor gene Sox8". Nucleic Acids Res 28 (6): 1473–80. PMC 111037. PMID 10684944. doi:10.1093/nar/28.6.1473. 
  3. ^ a b "Entrez Gene: SOX8 SRY (sex determining region Y)-box 8". 

Further reading

</dl>

Template:Gene-16-stub