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SPEG

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Identifiers
SymbolsSPEG ; APEG-1; APEG1; BPEG; SPEGalpha; SPEGbeta
External IDsHomoloGene55619 IUPHAR: 2203 GeneCards: SPEG Gene
EC number2.7.11.1
Orthologs
SpeciesHumanMouse
Entrez1029011790
EnsemblENSG00000072195ENSMUSG00000026207
UniProtQ15772Q62407
RefSeq (mRNA)NM_001173476NM_001085370
RefSeq (protein)NP_001166947NP_001078839
Location (UCSC)Chr 2:
220.3 – 220.36 Mb
Chr 1:
75.38 – 75.43 Mb
PubMed search[1][2]

SPEG complex locus, also known as SPEG, is a human gene.[1]

Expression of this gene is thought to serve as a marker for differentiated vascular smooth muscle cells which may have a role in regulating growth and differentiation of this cell type. The encoded protein is highly similar to the corresponding rat and mouse proteins. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of only one variant has been defined.[1]

Mouse Mutant Alleles for Speg
Marker Symbol for Mouse Gene. This symbol is assigned to the genomic locus by the MGI Speg
Mutant Mouse Embryonic Stem Cell Clones. These are the known targeted mutations for this gene in a mouse. Spegtm1a(KOMP)Wtsi
Example structure of targeted conditional mutant allele for this gene
These Mutant ES Cells can be studied directly or used to generate mice with this gene knocked out. Study of these mice can shed light on the function of Speg:

see Knockout mouse

References

Further reading

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External links


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