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Open Access Articles- Top Results for SR-57227

SR-57227

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SR-57227
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Systematic (IUPAC) name
1-(6-chloropyridin-2-yl)piperidin-4-amine
Clinical data
Identifiers
77145-61-0
PubChem CID 131747
Chemical data
Formula C10H14ClN3
211.69 g/mol

SR-57227 is a potent and selective agonist at the 5HT3 receptor, with high selectivity over other serotonin receptor subtypes and good blood-brain barrier penetration.[1][2][3][4]

References

  1. ^ Bachy, A.; Héaulme, M.; Giudice, A.; Michaud, J. C.; Lefevre, I. A.; Souilhac, J.; Manara, L.; Emerit, M. B.; Gozlan, H.; Hamon, M.; Keane, P. E.; Soubrié, P.; Le Fur, G. R. (1993). "SR 57227A: A potent and selective agonist at central and peripheral 5-HT3 receptors in vitro and in vivo". European journal of pharmacology 237 (2–3): 299–309. PMID 7689975. doi:10.1016/0014-2999(93)90282-M.  edit
  2. ^ Maksay, G.; Simonyi, M.; Bikádi, Z. (2004). "Subunit rotation models activation of serotonin 5-HT3AB receptors by agonists". Journal of computer-aided molecular design 18 (10): 651–664. PMID 15849995. doi:10.1007/s10822-004-6259-0.  edit
  3. ^ Yoo, J. H.; Cho, J. H.; Yu, H. S.; Lee, K. W.; Lee, B. H.; Jeong, S. M.; Nah, S. Y.; Kim, H. C.; Lee, S. Y.; Jang, C. G. (2006). "Involvement of 5-HT3receptors in the development and expression of methamphetamine-induced behavioral sensitization: 5-HT3Areceptor channel and binding study". Journal of Neurochemistry 99 (3): 976–988. PMID 16942594. doi:10.1111/j.1471-4159.2006.04137.x.  edit
  4. ^ Li, Y.; Raaby, K. F.; Sánchez, C.; Gulinello, M. (2013). "Serotonergic receptor mechanisms underlying antidepressant-like action in the progesterone withdrawal model of hormonally induced depression in rats". Behavioural Brain Research 256: 520–528. PMID 24016840. doi:10.1016/j.bbr.2013.09.002.  edit



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