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Open Access Articles- Top Results for SR 59230A

SR 59230A

SR 59230A
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IUPAC name
(2S)-1-(2-ethylphenoxy)-3-{[(1S)-1,2,3, 4-tetrahydronaphthalen-1-yl]amino}propan-2-ol
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174689-39-5 7pxY
IUPHAR ligand 547
Jmol-3D images Image
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C21H27NO2
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Infobox references

SR 59230A is a selective antagonist of the beta-3 adrenergic receptor,[1][2][3] but was subsequently shown to also act at α1 adrenoceptors at high doses.[4] It has been shown to block the hyperthermia produced by MDMA in animal studies.[5]

References

  1. Nisoli E, Tonello C, Landi M, Carruba MO (1996). "Functional studies of the first selective β3-adrenergic receptor antagonist SR 59230A in rat brown adipocytes". Mol. Pharmacol. 49 (1): 7–14. PMID 8569714. 
  2. Bellantuono V, Cassano G, Lippe C (August 2008). "The adrenergic receptor subtypes present in frog (Rana esculenta) skin". Comp. Biochem. Physiol. C Toxicol. Pharmacol. 148 (2): 160–4. PMID 18544474. doi:10.1016/j.cbpc.2008.05.001. 
  3. Rickenbacher A, Seiler R, Honegger U, Shaw SG, Balsiger BM (January 2008). "Role of beta1-, beta2-, and beta3-adrenoceptors in contractile hypersensitivity in a model of small bowel transplantation". Surgery 143 (1): 94–102. PMID 18154937. doi:10.1016/j.surg.2007.06.034. 
  4. Leblais V, Pourageaud F, Ivorra MD, Guibert C, Marthan R, Muller B (April 2004). "Role of alpha-adrenergic receptors in the effect of the beta-adrenergic receptor ligands, CGP 12177, bupranolol, and SR 59230A, on the contraction of rat intrapulmonary artery". J. Pharmacol. Exp. Ther. 309 (1): 137–45. PMID 14718590. doi:10.1124/jpet.103.061192. 
  5. Bexis S, Docherty JR (April 2009). "Role of alpha(1)- and beta(3)-adrenoceptors in the modulation by SR59230A of the effects of MDMA on body temperature in the mouse". British Journal of Pharmacology 158 (1): 259–66. PMC 2795232. PMID 19422394. doi:10.1111/j.1476-5381.2009.00186.x. 

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