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Open Access Articles- Top Results for STK10

STK10

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Identifiers
SymbolsSTK10 ; LOK; PRO2729
External IDsOMIM603919 MGI1099439 HomoloGene38122 IUPHAR: 2211 ChEMBL: 3981 GeneCards: STK10 Gene
EC number2.7.11.1
RNA expression pattern
File:PBB GE STK10 40420 at tn.png
File:PBB GE STK10 203047 at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez679320868
EnsemblENSG00000072786ENSMUSG00000020272
UniProtO94804O55098
RefSeq (mRNA)NM_005990NM_009288
RefSeq (protein)NP_005981NP_033314
Location (UCSC)Chr 5:
171.47 – 171.62 Mb
Chr 11:
32.53 – 32.62 Mb
PubMed search[1][2]

Serine/threonine-protein kinase 10 is an enzyme that in humans is encoded by the STK10 gene.[1][2]

This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. The protein can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. The kinase can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway.[2]

References

  1. ^ Kuramochi S, Matsuda Y, Okamoto M, Kitamura F, Yonekawa H, Karasuyama H (Jun 1999). "Molecular cloning of the human gene STK10 encoding lymphocyte-oriented kinase, and comparative chromosomal mapping of the human, mouse, and rat homologues". Immunogenetics 49 (5): 369–75. PMID 10199912. doi:10.1007/s002510050509. 
  2. ^ a b "Entrez Gene: STK10 serine/threonine kinase 10". 

Further reading

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