Open Access Articles- Top Results for Salmonella typhi
Biosensors JournalBlocking Non-Specific Binding for Phage-Based Magnetoelastic Biosensors
International Journal of Pharma Research & ReviewIn-virto Antimicrobial activity of Medicinally Important Plant-Cardiospermum helicacabum Linn. against Pathogenic Bacteria
Journal of Health & Medical InformaticsThe Integrated Management System for Salmonella Control Plan in Italy
Research & Reviews: Journal of Food Processing and Dairy TechnologyBehavior of Salmonella typhimurium DT104 during the Manufacturing of Ergo and Ayib, Ethiopian Traditional Fermented Milk Products
Journal of Infectious Diseases & TherapyMiracle Remedy: Inhibition of Bacterial Efflux Pumps by Natural Products
Salmonella enterica subsp. enterica
Salmonella enterica subsp. enterica is a subspecies of Salmonella enterica, the rod-shaped, flagellated, aerobic, Gram-negative bacterium. It is a member of the genus Salmonella. Many of the pathogenic serovars of the S. enterica species are in this subspecies, including that responsible for typhoid.
S. enterica subsp. enterica contains a large number of serovars which can infect a broad range of vertebrate hosts. The individual members range from being highly host-adapted (only able to infect a narrow range of species) and displaying a broad host range. A number of techniques are currently used to differentiate between serotypes. These include looking for the presence or absence of antigens, phage typing, molecular fingerprinting and biotyping, where serovars are differentiated by which nutrients they are able to ferment. A possible factor in determining the host range of particular serovars is phage-mediated acquisition of a small number of genetic elements that enable infection of a particular host. It is further postulated that serovars which infect a narrow range of species have diverged from ancestors with a broad host range, and have since specialised and lost the ability to infect some hosts.
A selection of serovars, with known hosts listed. Since there are more than 2500 serovars of Salmonella enterica subsp. enterica, this list is incomplete.
|Salmonella Enteritidis||Humans, rodents, galliformes|
|Salmonella Hadar||Humans, galliformes, rabbits|
|Salmonella Heidelberg||Humans, galliformes, swine|
|Salmonella Infantis||Humans, poultry|
|Salmonella Typhimurium||Infects humans, cattle, swine, sheep, horses, rodents, galliformes|
Genetic evidence suggests that the serovars can be divided into two groups - one which causes enteric infection and has a broad repertoire of metabolic capabilities, and one which usually causes invasive infection, often in a narrow range of hosts, and shows degradation of anaerobic metabolic pathways. It is thought that these metabolic capabilities are important for obtaining nutrients in the challenging and nutrient-limited inflamed gut environment.
The serovars can be designated fully or in a shortened form. The short form lists the genus, Salmonella, which is followed by the capitalized and non-italicized serovar. The full designation for Salmonella Typhi is Salmonella enterica subsp. enterica, serovar Typhi. Each serovar can have many strains, as well, which allows for a rapid increase in the total number of antigenically variable bacteria.
Invasive strains of non-typhoidal salmonella, such as S Typhimurium ST313 have recently been labelled as emerging diseases in Africa. Key host immune deficiencies associated with HIV, malaria and malnutrition have contributed to a wide spread of this disease and the need to use expensive antimicrobial drugs in the poorest health services in the world.
- Giannella RA (1996). Salmonella. In: Baron's Medical Microbiology (Barron S et al., eds.) (4th ed.). Univ of Texas Medical Branch. (via NCBI Bookshelf) ISBN 0-9631172-1-1.
- Murray PR, Rosenthal KS, Pfaller MA (2009). Medical Microbiology (6th ed.). Philadelphia, PA: Mosby Elsevier. p. 307.
- Rabsch, Wolfgang; Andrews, Helene L.; Kingsley, Robert A.; Prager, Rita; Tschape, Helmut; Adams, Garry; Baumler, Andreas J. (2002). "Salmonella enterica Serotype Typhimurium and Its Host-Adapted Variants". Infection and Immunity 70 (5): 2249–2255. doi:10.1128/IAI.70.5.2249-2255.2002.
- Langridge, Gemma C.; Fookes, Maria; Connor, Thomas; Feltwell, Theresa; Feasey, Nicholas; Parsons, Bryony; Seth-Smith, Helena; Barquist, Lars; Stedman, Anna; Humphrey, Thomas; Wigley, Paul; Peters, Sarah; Maskell, Duncan; Corander, Jukka; Chabalgoity, Jose; Barrow, Paul; Parkhill, Julian; Dougan, Gordon; Thomson, Nicholas (2014). "Patterns of genome evolution that have accompanied host adaptation in Salmonella". PNAS. Early Edition.
- "Snapshots of Salmonella Serotypes" (PDF). Centers for Disease Control and Prevention. CDC.
- Nuccio, Sean-Paul; Baumler, Andreas (2014). "Comparative Analysis of Salmonella Genomes Identifies a Metabolic Network for Escalating Growth in the Inflamed Gut". mBio 5 (2): e00929–14. doi:10.1128/mBio.00929-14.
- Feasey, Nicholas A.; Dougan, Gordon; Kingsley, Robert A.; Heyderman, Robert S.; Gordon, Melita A. (2012). "Invasive non-typhoidal salmonella disease: an emerging and neglected tropical disease in Africa". The Lancet 379: 2489–99.
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