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Open Access Articles- Top Results for Sarcospan

Sarcospan

sarcospan
Identifiers
Symbol SSPN
Entrez 8082
HUGO 11322
OMIM 601599
Other data
Locus Chr. 12 p11.2

Sarcospan, discovered by the research group of Kevin Campbell, is a 25-kDa transmembrane protein located in the dystrophin-associated protein complex of skeletal muscle cells. It contains four transmembrane spanning helices with both N- and C-terminal domains located intracellularly.[1] Loss of sarcospan expression occurs in patients with Duchenne muscular dystrophy, indicating that dystrophin is required for proper localization of sarcospan.[1] Sarcospan knockout mice exhibit normal muscle structure and function, indicating that sarcospan is not necessary for muscle to develop.[2]

References

  1. ^ a b Crosbie; Heighway, J; Venzke, DP; Lee, JC; Campbell, KP et al. (1997). "Sarcospan, the 25-kDa transmembrane component of the dystrophin-glycoprotein complex". J Biol Chem 272 (50): 31221–4. PMID 9395445. doi:10.1074/jbc.272.50.31221. 
  2. ^ Lebakken; Venzke, DP; Hrstka, RF; Consolino, CM; Faulkner, JA; Williamson, RA; Campbell, KP et al. (2000). "Sarcospan-deficient mice maintain normal muscle function.". Mol Cell Biol 20 (5): 1669–77. PMC 85350. PMID 10669744. doi:10.1128/MCB.20.5.1669-1677.2000. 

External links


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