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Open Access Articles- Top Results for Sarmazenil

Sarmazenil

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Sarmazenil
File:Sarmazenil.png
Systematic (IUPAC) name
Ethyl 7-chloro-5-methyl-6-oxo-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate
Clinical data
AHFS/Drugs.com International Drug Names
Identifiers
78771-13-8 7pxY
QV03AB91
PubChem CID 71231
ChemSpider 64366 7pxN
UNII F84AE7X24P 7pxY
ChEMBL CHEMBL46547 7pxN
Chemical data
Formula C15H14ClN3O3
319.743 g/mol
 14pxN (what is this?)  (verify)

Sarmazenil (Ro15-3505) is a drug from the benzodiazepine family. It acts as a partial inverse agonist of benzodiazepine receptors,[1] meaning that it causes the opposite effects to most benzodiazepine drugs, and instead acts as an anxiogenic and convulsant. It is used in veterinary medicine to reverse the effects of benzodiazepine sedative drugs in order to rapidly re-awaken anesthetized animals.[2][3][4]

See also

References

  1. ^ López-Romero B, Evrard G, Durant F, Sevrin M, George P (1998). "Molecular structure and stereoelectronic properties of sarmazenil--a weak inverse agonist at the omega modulatory sites (benzodiazepine receptors): comparison with bretazenil and flumazenil". Bioorganic and Medicinal Chemistry 6 (10): 1745–57. PMID 9839004. doi:10.1016/S0968-0896(98)00117-5. 
  2. ^ Henke J, Roberts U, Otto K, Lendl C, Matis U, Brill T, Erhardt W (1996). "Clinical investigations of an i.m. combination anesthesia with fentanyl / climazolam / xylazine and postoperative i.v. antagonism with naloxone / sarmazenil / yohimbine in guinea pigs". Tierärztliche Praxis (in German) 24 (1): 85–7. PMID 8720962. 
  3. ^ Janovsky M, Tataruch F, Ambuehl M, Giacometti M (2000). "A Zoletil-Rompun mixture as an alternative to the use of opioids for immobilization of feral red deer". Journal of Wildlife Diseases 36 (4): 663–9. PMID 11085427. doi:10.7589/0090-3558-36.4.663. 
  4. ^ Walzer C, Huber C (2002). "Partial antagonism of tiletamine-zolazepam anesthesia in cheetah". Journal of Wildlife Diseases 38 (2): 468–72. PMID 12038151. doi:10.7589/0090-3558-38.2.468. 


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