Adverts

Open Access Articles- Top Results for Satavaptan

Satavaptan

</th></tr>
Satavaptan
280px
Systematic (IUPAC) name
N-(tert-butyl)-4-{[(1s,4s)-5'-ethoxy-4-(2-morpholin-4-ylethoxy)-2'-oxospiro[cyclohexane-1,3'-indol]-1'(2'H)-yl]sulfonyl}-3-methoxybenzamide
Clinical data
Identifiers
185913-78-4 7pxY
None
PubChem CID 9810773
ChemSpider 32699105 7pxN
UNII AJS8S3P31H 7pxY
Chemical data
Formula C33H45N3O8S
643.789 g/mol
 14pxN (what is this?)  (verify)

Satavaptan (INN; codenamed SR121463, planned tradename Aquilda) is a vasopressin-2 receptor antagonist[1] undergoing research for the treatment of hyponatremia. It is also being studied for the treatment of ascites.[2]

It was developed by Sanofi-Aventis. As of 2008, it is under regulatory review in the European Union.

References

  1. ^ Soupart A; Gross P; Legros JJ et al. (November 2006). "Successful long-term treatment of hyponatremia in syndrome of inappropriate antidiuretic hormone secretion with satavaptan (SR121463B), an orally active nonpeptide vasopressin V2-receptor antagonist". Clin J Am Soc Nephrol 1 (6): 1154–1160. PMID 17699341. doi:10.2215/CJN.00160106. 
  2. ^ Ginès P, Wong F, Watson H, Milutinovic S, Ruiz Del Arbol L, Olteanu D (February 2008). "Effects of satavaptan, a selective vasopressin V(2) receptor antagonist, on ascites and serum sodium in cirrhosis with hyponatremia: A randomized trial". Hepatology 48 (1): 204–213. PMID 18508290. doi:10.1002/hep.22293. 



Lua error in package.lua at line 80: module 'Module:Buffer' not found.