|Systematic (IUPAC) name|
Selurampanel (INN, code name BGG492) is a drug closely related to the quinoxalinedione series which acts as a competitive antagonist of the AMPA and kainate receptors and, as of 2015, is being investigated in clinical trials by Novartis for the treatment of epilepsy. It has also been studied in the acute treatment of migraine, and was found to produce some pain relief, but with a relatively high rate of side effects.
- Faught, Edward (2014). "BGG492 (selurampanel), an AMPA/kainate receptor antagonist drug for epilepsy". Expert Opinion on Investigational Drugs 23 (1): 107–113. ISSN 1354-3784. doi:10.1517/13543784.2014.848854.
- Belcastro, Vincenzo; Verrotti, Alberto (2015). "Novel Molecular Targets for Drug-Treatment of Epilepsy". pp. 183–199. doi:10.1007/978-3-319-12283-0_10.
- Hanada, Takahisa (2014). "The AMPA receptor as a therapeutic target in epilepsy: preclinical and clinical evidence". Journal of Receptor, Ligand and Channel Research: 39. ISSN 1178-699X. doi:10.2147/JRLCR.S51475.
- Gomez-Mancilla B, Brand R, Jürgens TP et al. (February 2014). "Randomized, multicenter trial to assess the efficacy, safety and tolerability of a single dose of a novel AMPA receptor antagonist BGG492 for the treatment of acute migraine attacks". Cephalalgia 34 (2): 103–13. PMID 23963355. doi:10.1177/0333102413499648.
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