Open Access Articles- Top Results for Seminal vesicle

Seminal vesicle

Seminal vesicle
Human Male Anatomy
Prostate with seminal vesicles and seminal ducts, viewed from in front and above.
Latin Vesiculae seminales
Precursor Wolffian duct
Inferior vesical artery, middle rectal artery
External iliac lymph nodes, internal iliac lymph nodes
Gray's p.1246
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Anatomical terminology

The seminal vesicles (Latin: glandulae vesiculosae), vesicular glands,[1] or seminal glands, are a pair of simple tubular glands posteroinferior to the urinary bladder of some male mammals. Seminal vesicles are located within the pelvis.


The seminal vesicles are a pair of glands that are positioned below the urinary bladder and lateral to the vas deferens. Each vesicle consists of a single tube folded and coiled on itself, with occasional diverticula in its wall.[2]

The excretory duct of each seminal gland unites with the corresponding vas deferens to form the two ejaculatory ducts, which immediately pass through the substance of the prostate gland before opening separately into the verumontanum of the prostatic urethra.[2][3]

Each seminal vesicle spans approximately 5 cm, though its full unfolded length is approximately 10 cm, but it is curled up inside the gland's structure.


Each vesicle forms as an outpocketing of the wall of the ampulla of one vas deferens. The seminal vesicles develop as one of three structures of the male reproductive system that develops at the junction between the urethra and vas deferens. Both the urethra and vas deferens are derived from the mesonephric ducts, structures that develop from mesoderm.[4]


Under microscopy, the seminal vesicles can be seen to have a mucosa, consisting of a lining of interspersed columnar cells and a laminar propria; and a thick muscular wall. The lumen of the glands is highly irregular and stores secretions from the glands of the vesicles. In detail:[5]

The height of these columnar cells, and therefore activity, is dependent upon testosterone levels in the blood.[citation needed]

  • The lamina propria, containing underlying small blood vessels and lymphatics. Together with the epithelia, this is called the mucosa, and is arranged into convoluted folds, increasing the overall surface area
  • A muscular layer, consisting of an inner circular and outer longitudinal layer of smooth muscle, can also be found.

Spermatozoa may occasionally be found within the lumen of the glands, even though the vesicles are blind-ended in nature. This is thought to be because of slight reflux due to muscular contractions of the urethera during ejaculation.[5]


The seminal vesicles secrete a significant proportion of the fluid that ultimately becomes semen. Lipofuscin granules from dead epithelial cells give the secretion its yellowish color. About 50-70%[6] of the seminal fluid in humans originates from the seminal vesicles, but is not expelled in the first ejaculate fractions which are dominated by spermatozoa and zinc-rich prostatic fluid. The excretory duct of each seminal gland opens into the corresponding vas deferens as it enters the prostate gland. Seminal vesicle fluid is alkaline, resulting in human semen having a mildly alkaline pH.[7] The alkalinity of semen helps neutralize the acidity of the vaginal tract[citation needed], prolonging the lifespan of sperm. Acidic ejaculate (pH <7.2) may be associated with ejaculatory duct obstruction. The vesicle produces a substance that causes the semen to become sticky and jelly-like after ejaculation.

The thick secretions from the seminal vesicles contain proteins, enzymes, fructose, mucus, vitamin C, flavins, phosphorylcholine and prostaglandins. The high fructose concentrations provide nutrient energy for the spermatozoa when stored in semen in the laboratory.

In vitro studies have shown that sperm expelled together with seminal vesicular fluid show poor motility and survival, and the sperm chromatin is less protected. Therefore the exact physiological importance of seminal vesicular fluid is not clear.[citation needed]

Additional images

Clinical significance

Physical examination of the seminal vesicles is difficult. Laboratory examination of seminal vesicle fluid requires a semen sample, e.g. for semen culture or semen analysis. Fructose levels provide a measure of seminal vesicle function and, if absent, bilateral agenesis or obstruction is suspected.[8]

Disorders of the seminal vesicles include seminal vesiculitis, acquired cysts, abscess, congenital anomalies (such as agenesis, hypoplasia and cysts), amyloidosis, tuberculosis, schistosomiasis, hydatid cyst, calculi and tumours.[8][9]


Seminal vesiculitis (also known as spermatocystitis) is an inflammation of the seminal vesicles, most often caused by bacterial infection. Symptoms of seminal vesiculitis can include vague back or lower abdominal pain; penile, scrotal, or perineal pain; painful ejaculation; hematospermia; irritative and obstructive voiding symptoms; and impotence.[10]

It is usually treated by administration of antibiotics. In intractable cases, in case of patient discomfort, transurethral seminal vesiculoscopy may be considered.[11][12]


  1. ^ Wilke; W. Lee Wilke; Rowen D. Frandson; Anna Dee Fails (2009). Anatomy and Physiology of Farm Animals. John Wiley and Sons. ISBN 0-8138-1394-8. Retrieved 2013-11-03. 
  2. ^ a b Michael H. Ross; Wojciech Pawlina (2010). "22". Histology: A Text and Atlas, 6th Edition. ISBN 978-0781772006. 
  3. ^ Drake, Richard L.; Vogl, Wayne; Tibbitts, Adam W.M. Mitchell; illustrations by Richard; Richardson, Paul (2005). Gray's anatomy for students. Philadelphia: Elsevier/Churchill Livingstone. pp. 407–409. ISBN 978-0-8089-2306-0. 
  4. ^ Larsen's human embryology (4th ed., Thoroughly rev. and updated. ed.). Philadelphia: Churchill Livingstone/Elsevier. 2009. pp. "Development of the urogenital system". ISBN 9780443068119.  |first1= missing |last1= in Authors list (help)
  5. ^ a b Deakin, Barbara Young ... [et al.] ; drawings by Philip J. (2006). Wheater's functional histology : a text and colour atlas (5th ed. ed.). [Edinburgh?]: Churchill Livingstone/Elsevier. p. 355. ISBN 978-0-443-06850-8. 
  6. ^ Kierszenbaum, Abraham L. (2002). Histology and cell biology : an introduction to pathology. St. Louis [u.a.]: Mosby. p. 558. ISBN 0-323-01639-1. 
  8. ^ a b El-Hakim, Assaad (November 13, 2006). "Diagnosis and Treatment of Disorders of the Ejaculatory Ducts and Seminal Vesicles". In Smith, Arthur D. Smith's Textbook of Endourology, 2nd Edition. Wiley-Blackwell. pp. 759–766. ISBN 978-1550093650. 
  9. ^ "Seminal vesicle diseases". Geneva Foundation for Medical Education and Research. 
  10. ^ Zeitlin, S. I.; Bennett, C. J. (November 1, 1999). "Chapter 25: Seminal vesiculitis". In Curtis Nickel, J. Textbook of Prostatitis. CRC Press. pp. 219–225. ISBN 9781901865042. 
  11. ^ La Vignera S (Oct 2011). "Male accessory gland infection and sperm parameters.". Int J Androl 42 (34): e330–47. PMID 21696400. doi:10.1111/j.1365-2605.2011.01200.x. 
  12. ^ Liu B (Feb 2014). "Transurethral seminal vesiculoscopy in the diagnosis and treatment of intractable seminal vesiculitis.". J Int Med Res 42 (1): 236–42. PMID 24391141. doi:10.1177/0300060513509472. 

External links

  • Histology image: 17501loa – Histology Learning System at Boston University - "Male Reproductive System: prostate, seminal vesicle"
  • Anatomy photo:44:04-0202 at the SUNY Downstate Medical Center - "The Male Pelvis: The Urinary Bladder"
  • Anatomy photo:44:08-0103 at the SUNY Downstate Medical Center - "The Male Pelvis: Structures Located Posterior to the Urinary Bladder"