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Open Access Articles- Top Results for Semustine

Semustine

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Semustine
File:Semustine.png
Systematic (IUPAC) name
N-(2-Chloroethyl)-N'-(4-methylcyclohexyl)-N-nitrosourea
Clinical data
Identifiers
13909-09-6 7pxY
L01AD03
PubChem CID 5198
ChemSpider 5009
UNII 6YY7T1T567 7pxY
KEGG D05822 7pxY
ChEBI CHEBI:6863 7pxN
Chemical data
Formula C10H18ClN3O2
247.72 g/mol
 14pxN (what is this?)  (verify)

Semustine is a drug used in chemotherapy.[1] It is structurally similar to lomustine, being distinguished from it only by an additional methyl group. It has been taken off the drug market for investigation of its cancerous effects, rated as IARC Group 1 carcinogen or a known carcinogen.[citation needed]

References

  1. "Radiation therapy and fluorouracil with or without semustine for the treatment of patients with surgical adjuvant adenocarcinoma of the rectum. Gastrointestinal Tumor Study Group". Journal of clinical oncology : official journal of the American Society of Clinical Oncology 10 (4): 549–557. 1992. PMID 1548520.  edit


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