Open Access Articles- Top Results for Sensodyne


Sensodyne is an oral health brand targeted at people with sensitive teeth.[1] Sensodyne products are applied at home by the patient to treat this condition. Sensodyne is owned by GlaxoSmithKline and is marketed under the name Shumitect in Japan.[2]


Sensodyne is a brand of toothpaste that was first sold by Block Drug, a Brooklyn, New York-based company established in 1907 by pharmacist, Alexander Block.[1] The toothpaste was first marketed in 1961 as a desensitising toothpaste based on a strontium chloride formulation.[citation needed]

In 1980,[citation needed] Sensodyne launched a new toothpaste containing potassium nitrate, a mild local sedative.[3] In 2000 Block Drug was purchased by GlaxoSmithKline.[1] In 2006, Sensodyne Pronamel was released and is marketed as a toothpaste that protects against the effects of dental erosion.[citation needed]

How Sensodyne Works

Sensodyne toothpastes work in one of three ways to relieve the pain of sensitive teeth*. Depending on the product's active ingredient - Potassium Nitrate, Strontium Acetate/Chloride, or NovaMin technology.

Potassium Nitrate: The potassium ion depolarizes the nerve and stops it from firing. The nerve impulses are thus desensitized and there is no pain.[4]

Clinical studies show potassium nitrate progressively reduces the pain of sensitivity over a period of weeks.[citation needed] As long as a toothpaste with potassium like Sensodyne is used twice daily in brushing, the nerve response will gradually be reduced and sensitivity pain is relieved.[citation needed]

Strontium Acetate & Chloride: These compounds share a similar chemical structure to calcium. Strontium based toothpastes (Acetate & Chloride) are therefore able replace some of the lost calcium and block the exposed tubules in the dentinal tissue. This helps prevent the movement of the fluid within the tubules in response to a sensitivity stimulus that could otherwise cause tooth pain.[4][5]

Bioactive glass: Newer Sensodyne products [6][7] contain calcium sodium phosphosilicate (Brand name NovaMin). NovaMin sticks to an exposed dentin surface and reacts with it to form a mineralized layer. The layer formed bonds with the tooth, and is therefore strong and resistant to acid. The continuous release of calcium over time is suggested to maintain the protective effects on dentin, and provide continual occlusion of the dentin tubules. [8][9]

See also


  1. ^ a b c Clark, Andrew (October 7, 2000). "SmithKline to swallow Sensodyne". The Guardian. Retrieved July 20, 2013. 
  2. ^
  3. ^ Ramirez, Anthony (May 13, 1990). "All About/Toothpaste; Growth Is Glacial, but the Market Is Big, and So Is the Gross". The New York Times. Retrieved July 20, 2013. 
  4. ^ a b "How Sensodyne Works". Sensodyne Australia. GlaxoSmithKline. Retrieved 21 November 2014. 
  5. ^ Hughes, N; Layer, T (2010). "Evidence for the efficacy of an 8% strontium acetate dentifrice for instant and lasting relief of dentin hypersensitivity.". Journal of Clinical Dentistry 21 (5): 56–58. PMID 20669817. 
  6. ^ "Sensodyne Repair & Protect". Sensodyne Australia. GlaxoSmithKline. 
  7. ^ "Sensodyne Complete Care". Sensodyne Australia. GlaxoSmithKline. Retrieved 21 November 2014. 
  8. ^ Goldie, Maria. "Potassium nitrate, sodium fluoride, strontium chloride, and NovaMin technologies for dentin hypersensitivity". Dentistry IQ. Retrieved 21 November 2014. 
  9. ^
  • Addy, Martin.Dentine Hypersensitivity: new perspectives on an old problem. International Dental Journal (2002) 52, 367–375.

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