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Setiptiline

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Setiptiline
200px
Systematic (IUPAC) name
2-methyl-2,3,4,9-tetrahydro-1H-dibenzo[3,4:6,7]cyclohepta[1,2-c]pyridine
Clinical data
AHFS/Drugs.com International Drug Names
  • (Prescription only)
Oral
Identifiers
0057262-94-9 7pxN
None
PubChem CID 5205
ChemSpider 5016 7pxY
UNII 7L38105Z6E 7pxY
KEGG D08511 7pxY
Chemical data
Formula C19H19N
261.36 g/mol
 14pxN (what is this?)  (verify)

Setiptiline (Tecipul), also known as teciptiline, is a tetracyclic antidepressant (TeCA) which acts as a noradrenergic and specific serotonergic antidepressant (NaSSA). It was launched in 1989 for the treatment of depression in Japan by Mochida.[1][2]

Chemistry

Setiptiline has a tetracyclic structure and is a close analogue of mianserin and mirtazapine, with setiptiline being delta(13b,4a),4a-carba-mianserin, and mirtazapine being 6-aza-mianserin.

Pharmacology

Setiptiline acts as a norepinephrine reuptake inhibitor,[3] α2-adrenergic receptor antagonist,[4] and serotonin receptor antagonist,[5] likely at the 5-HT2A, 5-HT2C, and/or 5-HT3 subtypes, as well as an H1 receptor inverse agonist/antihistamine.[3]

See also

References

  1. ^ Buschmann, H.; Torrens, A.; Vela, J. M. (2007). Antidepressants, Antipsychotics, Anxiolytics: From Chemistry and Pharmacology to Clinical Application 1. Wiley VCH. p. 248. ISBN 978-3-527-31058-6. 
  2. ^ Swiss Pharmaceutical Society, ed. (2000). Index Nominum 2000: International Drug Directory. Medpharm Scientific Publishers. p. 942. ISBN 3-88763-075-0. 
  3. ^ a b Niho, T.; Ito, C.; Shibutani, Y.; Hashizume, H.; Yamaguchi, K. (1986). "Pharmacological Properties of MO-8282, a Novel Antidepressant". Nihon yakurigaku zasshi. Folia Pharmacologica Japonica 88 (4): 309–320. PMID 3792961. doi:10.1254/fpj.88.309.  edit
  4. ^ Mizota, M.; Oikawa, Y.; Nakayama, K.; Mizuguchi, K.; Takarada, T.; Kojima, M.; Kanehiro, H.; Funato, H.; Kayamoto, M.; Sato, M.; Niho, T. (1986). "Pharmacological Studies of MO-8282, a New Antidepressant". Nihon yakurigaku zasshi. Folia Pharmacologica Japonica 88 (6): 457–466. PMID 2881854. doi:10.1254/fpj.88.457.  edit
  5. ^ Przegaliński, E.; Baran, L.; Siwanowicz, J.; Rawłów, A. (1986). "The Lack of Antidepressant Properties and a Potent Central Antiserotonin Activity of Org 8282". Polish Journal of Pharmacology and Pharmacy 38 (4): 377–384. PMID 3774630.  edit



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