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Open Access Articles- Top Results for Setoperone

Setoperone

Setoperone
200px
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This page is a soft redirect. Names

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IUPAC name
6-[2-[4-[(4-Fluorophenyl)-oxomethyl]-1-piperidinyl]ethyl]-7-methyl-2,3-dihydrothiazolo[2,3-b]pyrimidin-5-one
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86487-64-1 7pxY
ChemSpider 61870 7pxN
Jmol-3D images Image
KEGG D02686 7pxY
PubChem Template:Chembox PubChem/format
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C21H24FN3O2S
Molar mass 401.50 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Setoperone is a compound that is a ligand to the 5-HT2A receptor. It can be radiolabeled with the radioisotope fluorine-18 and used as a radioligand with positron emission tomography (PET). Several research studies have used the radiolabeled setoperone in neuroimaging for the studying neuropsychiatric disorders, such as depression[1] or schizophrenia.[2]

References

  1. ^ Jeffrey H. Meyer, Shitij Kapur, Sylvain Houle, Jean DaSilva, Beata Owczarek, Gregory M. Brown, Alan A. Wilson and Sidney H. Kennedy (July 1, 1999). "Prefrontal Cortex 5-HT2 Receptors in Depression: An [18F]Setoperone PET Imaging Study". American Journal of Psychiatry 156 (7): 1029–1034. PMID 10401447. 
  2. ^ Ralph Lewis, Shitij Kapur, Corey Jones, Jean DaSilva, Gregory M. Brown, Alan A. Wilson, Sylvain Houle and Robert B. Zipursky (January 1, 1999). "Serotonin 5-HT2 Receptors in Schizophrenia: A PET Study Using [18F]Setoperone in Neuroleptic-Naive Patients and Normal Subjects". American Journal of Psychiatry 156 (1): 72–78. PMID 9892300. 


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