Open Access Articles- Top Results for Sinomenine


Systematic (IUPAC) name
Clinical data
115-53-7 7pxY
PubChem CID 5459308
ChEMBL CHEMBL248095 7pxN
Synonyms Cocculine
Chemical data
Formula C19H23NO4
329.390 g/mol
 14pxN (what is this?)  (verify)

Sinomenine or cocculine is an alkaloid found in the root of the climbing plant Sinomenium acutum which is native to Japan and China. It is traditionally used in herbal medicine in these countries, as a treatment for rheumatism and arthritis.[1] However, its analgesic action against other kinds of pain is limited. Sinomenine is a morphinan derivative, related to opioids such as levorphanol and the non-opioid cough suppressant dextromethorphan. Its anti-rheumatic effects are thought to be primarily mediated via release of histamine,[2] but other effects such as inhibition of prostaglandin, leukotriene and nitric oxide synthesis may also be involved.[3]

See also


  1. ^ Zhao, ZZ; Liang, ZT; Zhou, H; Jiang, ZH; Liu, ZQ; Wong, YF; Xu, HX; Liu, L (2005). "Quantification of sinomenine in caulis sinomenii collected from different growing regions and wholesale herbal markets by a modified HPLC method". Biological & pharmaceutical bulletin 28 (1): 105–9. PMID 15635172. doi:10.1248/bpb.28.105. 
  2. ^ Yamasaki, H (1976). "Pharmacology of sinomenine, an anti-rheumatic alkaloid from Sinomenium acutum". Acta medica Okayama 30 (1): 1–20. PMID 61710. 
  3. ^ Liu, L; Riese, J; Resch, K; Kaever, V (1994). "Impairment of macrophage eicosanoid and nitric oxide production by an alkaloid from Sinomenium acutum". Arzneimittel-Forschung 44 (11): 1223–6. PMID 7848335.