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Sodium orthovanadate

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Sodium orthovanadate
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This page is a soft redirect. Names

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IUPAC name
Sodium vanadate(V)
Other names
sodium vanadate (V),
sodium vanadium oxide
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13721-39-6 7pxY
ChEMBL ChEMBL179166 7pxN
Jmol-3D images Image
PubChem Template:Chembox PubChem/format
RTECS number YW1120000
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This page is a soft redirect. Properties

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Na3VO4
Molar mass 183.908 g/mol
Appearance white powder
Density 2.16 g/cm³, solid
Melting point Script error: No such module "convert".
22.17 g/100 mL
Solubility insoluble in ethanol
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Crystal structure cubic
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164.8 J/mol K
190 J/mol K
-1757 kJ/mol
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Main hazards Harmful.
NFPA 704

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1
2
0
Flash point Non-flammable
330 mg/kg (oral, rat)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Sodium orthovanadate is the chemical compound Na3VO4 and contains the tetrahedral VO43−.[1] It is an inhibitor of protein tyrosine phosphatases, alkaline phosphatases and a number of ATPases, most likely acting as a phosphate analogue. The VO43− ion binds reversibly to the active sites of most protein tyrosine phosphatases.

It is often added to buffer solutions that are used in protein analysis in molecular biology. The aim is to preserve the phosphorylation of proteins of interest by inhibiting endogenous phosphatases present in cell lysate mixture. It is commonly used at a final working concentration of 1 - 10 mM. It is toxic when inhaled, swallowed or in contact with skin.

Synthesis

Sodium orthovanadate is created by dissolving vanadium(V) oxide in a solution of sodium hydroxide.

References

  1. ^ Greenwood, Norman N.; Earnshaw, Alan (1997). Chemistry of the Elements (2nd ed.). Butterworth-Heinemann. ISBN 0080379419. 
Swarup, G. et al. Biochem. Biophys. Res. Comm. 107: 1104-1109 (1982).

See also