Open Access Articles- Top Results for Sodoku


Not to be confused with Sudoku or Sudeki.
Classification and external resources
ICD-10 A25.0
ICD-9 026.0
DiseasesDB 32803
MedlinePlus 001348
NCI Sodoku
Patient UK Sodoku
MeSH D011906

Sodoku (鼠毒) is a bacterial zoonotic disease. It is caused by the gram-negative rod Spirillum minus (also known as Spirillium minor). It is a form of rat-bite fever (RBF).[1]


The infections are acquired through rat bites or scratches. It can occur as nosocomial infections (i.e., acquired from hospitals), or due to exposure or close associations with animals preying on rats, mice, squirrels etc. Sodoku is mostly seen in Asia. The incubation period is 4 to 28 days.

Presentation and symptoms

The initial scratch or wound caused by a bite from a carrier rodent will result in mild inflammatory reactions and ulcerations. The wounds may heal initially, but reappear with the onset of symptoms. The symptoms include recurring fever, with body temperature 101–104 °F (38–40°C). The fever lasts for 2–4 days but recur generally at 4–8 weeks. This cycle may continue for months or years together. The other symptoms include regional lymphadenitis, malaise and headache. The complications include myocarditis, endocarditis, hepatitis, splenomegaly and meningitis.


Mortality ranges from 6-10%.


  1. ^ Elliott, S. P. (11 January 2007). "Rat Bite Fever and Streptobacillus moniliformis". Clinical Microbiology Reviews 20 (1): 13–22. PMC 1797630. PMID 17223620. doi:10.1128/CMR.00016-06.