Open Access Articles- Top Results for Somatostatin receptor 2

Somatostatin receptor 2

External IDsOMIM182452 MGI98328 HomoloGene37427 IUPHAR: 356 ChEMBL: 1804 GeneCards: SSTR2 Gene
RNA expression pattern
File:PBB GE SSTR2 214597 at tn.png
File:PBB GE SSTR2 217455 s at tn.png
More reference expression data
RefSeq (mRNA)NM_001050NM_001042606
RefSeq (protein)NP_001041NP_001036071
Location (UCSC)Chr 17:
71.16 – 71.17 Mb
Chr 11:
113.62 – 113.63 Mb
PubMed search[1][2]

Somatostatin receptor type 2 is a protein that in humans is encoded by the SSTR2 gene.[1]

Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR2 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in cerebrum and kidney.[2]


Somatostatin receptor 2 has been shown to interact with SHANK2.[3]

Therapeutic targeting

Most pituitary adenomas express SSTR2, but other somatostatin receptors are also found.<[4] Somatostatin analogs (i.e. Octreotide, Lanreotide ) are used to stimulate this receptors, and thus to inhibit further tumor proliferation.[5]

See also


  1. ^ Yamada Y, Stoffel M, Espinosa R 3rd, Xiang KS, Seino M, Seino S, Le Beau MM, Bell GI (Apr 1993). "Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms". Genomics 15 (2): 449–52. PMID 8449518. doi:10.1006/geno.1993.1088. 
  2. ^ "Entrez Gene: SSTR2 somatostatin receptor 2". 
  3. ^ Zitzer, H; Hönck H H; Bächner D; Richter D; Kreienkamp H J (Nov 1999). "Somatostatin receptor interacting protein defines a novel family of multidomain proteins present in human and rodent brain". J. Biol. Chem. (UNITED STATES) 274 (46): 32997–3001. ISSN 0021-9258. PMID 10551867. doi:10.1074/jbc.274.46.32997. 
  4. ^ Miller GM, Alexander JM, Bikkal HA, Katznelson L, Zervas NT, Klibanski A (April 1995). "Somatostatin receptor subtype gene expression in pituitary adenomas". J. Clin. Endocrinol. Metab. 80 (4): 1386–92. PMID 7714115. doi:10.1210/jcem.80.4.7714115. 
  5. ^ Zatelli MC, Ambrosio MR, Bondanelli M, Uberti EC (April 2007). "Control of pituitary adenoma cell proliferation by somatostatin analogs, dopamine agonists and novel chimeric compounds". Eur. J. Endocrinol. 156 Suppl 1: S29–35. PMID 17413185. doi:10.1530/eje.1.02352. 

Further reading


External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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