Open Access Articles- Top Results for Somatostatin receptor 4

Somatostatin receptor 4

SymbolsSSTR4 ; SS-4-R; SS4-R; SS4R
External IDsOMIM182454 MGI105372 HomoloGene20286 IUPHAR: 358 ChEMBL: 1853 GeneCards: SSTR4 Gene
RNA expression pattern
File:PBB GE SSTR4 214556 at tn.png
More reference expression data
RefSeq (mRNA)NM_001052NM_009219
RefSeq (protein)NP_001043NP_033245
Location (UCSC)Chr 20:
23.04 – 23.04 Mb
Chr 2:
148.4 – 148.4 Mb
PubMed search[1][2]

Somatostatin receptor type 4 is a protein that in humans is encoded by the SSTR4 gene.[1][2]

Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR4 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in fetal and adult brain and lung.[2]

See also


  1. ^ Rohrer L, Raulf F, Bruns C, Buettner R, Hofstaedter F, Schule R (Jun 1993). "Cloning and characterization of a fourth human somatostatin receptor". Proc Natl Acad Sci U S A 90 (9): 4196–200. PMC 46473. PMID 8483934. doi:10.1073/pnas.90.9.4196. 
  2. ^ a b "Entrez Gene: SSTR4 somatostatin receptor 4". 

Further reading

  • Patel YC (1999). "Somatostatin and its receptor family". Frontiers in neuroendocrinology 20 (3): 157–98. PMID 10433861. doi:10.1006/frne.1999.0183. 
  • Yamada Y; Post SR; Wang K et al. (1992). "Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney". Proc. Natl. Acad. Sci. U.S.A. 89 (1): 251–5. PMC 48214. PMID 1346068. doi:10.1073/pnas.89.1.251. 
  • Demchyshyn LL; Srikant CB; Sunahara RK et al. (1993). "Cloning and expression of a human somatostatin-14-selective receptor variant (somatostatin receptor 4) located on chromosome 20". Mol. Pharmacol. 43 (6): 894–901. PMID 8100352. 
  • Yasuda K; Espinosa R; Davis EM et al. (1993). "Human somatostatin receptor genes: localization of SSTR5 to human chromosome 20p11.2". Genomics 17 (3): 785–6. PMID 8244401. doi:10.1006/geno.1993.1410. 
  • Yamada Y; Kagimoto S; Kubota A et al. (1993). "Cloning, functional expression and pharmacological characterization of a fourth (hSSTR4) and a fifth (hSSTR5) human somatostatin receptor subtype". Biochem. Biophys. Res. Commun. 195 (2): 844–52. PMID 8373420. doi:10.1006/bbrc.1993.2122. 
  • Kaupmann K; Bruns C; Hoyer D et al. (1993). "Distribution and second messenger coupling of four somatostatin receptor subtypes expressed in brain". FEBS Lett. 331 (1–2): 53–9. PMID 8405411. doi:10.1016/0014-5793(93)80296-7. 
  • Yamada Y; Stoffel M; Espinosa R et al. (1993). "Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms". Genomics 15 (2): 449–52. PMID 8449518. doi:10.1006/geno.1993.1088. 
  • Xu Y, Song J, Bruno JF, Berelowitz M (1993). "Molecular cloning and sequencing of a human somatostatin receptor, hSSTR4". Biochem. Biophys. Res. Commun. 193 (2): 648–52. PMID 8512564. doi:10.1006/bbrc.1993.1673. 
  • Fukusumi S; Kitada C; Takekawa S et al. (1997). "Identification and characterization of a novel human cortistatin-like peptide". Biochem. Biophys. Res. Commun. 232 (1): 157–63. PMID 9125122. doi:10.1006/bbrc.1997.6252. 
  • de Lecea L; Ruiz-Lozano P; Danielson PE et al. (1997). "Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin". Genomics 42 (3): 499–506. PMID 9205124. doi:10.1006/geno.1997.4763. 
  • Jaïs P; Terris B; Ruszniewski P et al. (1997). "Somatostatin receptor subtype gene expression in human endocrine gastroentero-pancreatic tumours". Eur. J. Clin. Invest. 27 (8): 639–44. PMID 9279525. doi:10.1046/j.1365-2362.1997.1740719.x. 
  • Sharma K, Patel YC, Srikant CB (1999). "C-terminal region of human somatostatin receptor 5 is required for induction of Rb and G1 cell cycle arrest". Mol. Endocrinol. 13 (1): 82–90. PMID 9892014. doi:10.1210/me.13.1.82. 
  • Forssell-Aronsson EB; Nilsson O; Bejegård SA et al. (2000). "111In-DTPA-D-Phe1-octreotide binding and somatostatin receptor subtypes in thyroid tumors". J. Nucl. Med. 41 (4): 636–42. PMID 10768564. 
  • Zatelli MC; Tagliati F; Taylor JE et al. (2001). "Somatostatin receptor subtypes 2 and 5 differentially affect proliferation in vitro of the human medullary thyroid carcinoma cell line tt". J. Clin. Endocrinol. Metab. 86 (5): 2161–9. PMID 11344221. doi:10.1210/jc.86.5.2161. 
  • Talme T; Ivanoff J; Hägglund M et al. (2001). "Somatostatin receptor (SSTR) expression and function in normal and leukaemic T-cells. Evidence for selective effects on adhesion to extracellular matrix components via SSTR2 and/or 3". Clin. Exp. Immunol. 125 (1): 71–9. PMC 1906108. PMID 11472428. doi:10.1046/j.1365-2249.2001.01577.x. 
  • Pasquali D; Notaro A; Esposito D et al. (2002). "[Somatostatin receptor genes expression and effects of octreotide on orbital fibroblasts from Graves' ophthalmopathy]". Minerva Endocrinol. 26 (3): 175–9. PMID 11753241. 
  • Deloukas P; Matthews LH; Ashurst J et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature 414 (6866): 865–71. PMID 11780052. doi:10.1038/414865a. 
  • Papotti M; Bongiovanni M; Volante M et al. (2002). "Expression of somatostatin receptor types 1-5 in 81 cases of gastrointestinal and pancreatic endocrine tumors. A correlative immunohistochemical and reverse-transcriptase polymerase chain reaction analysis". Virchows Arch. 440 (5): 461–75. PMID 12021920. doi:10.1007/s00428-002-0609-x. 

External links

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