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Open Access Articles- Top Results for Stepholidine

Stepholidine

(−)-Stepholidine
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IUPAC name
(13aS)-3,9-dimethoxy-5,8,13,13a-tetrahydro-6H-isoquino[3,2-a]isoquinoline-2,10-diol
Other names
l-Stepholidine
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16562-13-3 7pxY
ChEMBL ChEMBL487387 7pxN
ChemSpider 5293188 7pxN
Jmol-3D images Image
MeSH Stepholidine
PubChem Template:Chembox PubChem/format
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C19H21NO4
Molar mass 327.374 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

(−)-Stepholidine is a naturally occurring chemical compound found in the herb Stephania intermedia. Stepholidine is a dual D2 receptor antagonist and D1 receptor agonist, and has shown antipsychotic activity in animal studies.[1][2][3][4]


See also

References

  1. ^ Natesan S, Reckless GE, Barlow KB et al. (August 2008). "The antipsychotic potential of l-stepholidine-a naturally occurring dopamine receptor D(1) agonist and D (2) antagonist". Psychopharmacology (Berl.) 199 (2): 275–89. PMID 18521575. doi:10.1007/s00213-008-1172-1. 
  2. ^ Mo J, Guo Y, Yang YS, Shen JS, Jin GZ, Zhen X (2007). "Recent developments in studies of l-stepholidine and its analogs: chemistry, pharmacology and clinical implications". Curr. Med. Chem. 14 (28): 2996–3002. PMID 18220736. doi:10.2174/092986707782794050. 
  3. ^ Jin GZ, Zhu ZT, Fu Y (January 2002). "(-)-Stepholidine: a potential novel antipsychotic drug with dual D1 receptor agonist and D2 receptor antagonist actions". Trends Pharmacol. Sci. 23 (1): 4–7. PMID 11804640. doi:10.1016/S0165-6147(00)01929-5. 
  4. ^ Fu W, Shen J, Luo X et al. (September 2007). "Dopamine D1 receptor agonist and D2 receptor antagonist effects of the natural product (-)-stepholidine: molecular modeling and dynamics simulations". Biophys. J. 93 (5): 1431–41. PMC 1948031. PMID 17468175. doi:10.1529/biophysj.106.088500. 


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