Open Access Articles- Top Results for Sticky platelet syndrome

Sticky platelet syndrome

Sticky platelet syndrome is a term used by some[1][2][3][4] to describe a disorder of platelet function.[5] It was first described by Mammen in 1983.[6] It is inherited in an autosomal dominant pattern.[7] It has not been associated with a specific gene, and it is not recognized as an entity in OMIM.

Among researchers using the term, it has been described as a coagulation disorder that can present in conjunction with protein S deficiency and Factor V Leiden.[8] It is not currently known if sticky platelet syndrome is a distinct condition, or if it represents part of the presentation of a more well characterized coagulation disorder.


SPS is diagnosed by demonstrating platelet hyperaggregability. In a lab test called aggregometry platelet stickyness is stimulated with epinephrine (EPI) and/or adenosine diphosphate (ADP).[9] This test is not possible for patients being treated with acetylsalicylic acid until that substance has sufficiently cleared from their system.


Those diagnosed are usually treated with taking a low dose (80–100 mg) Aspirin a day.[10] Anticoagulants (e.g. Warfarin, Coumadin) or clopidogrel (Plavix) are often additionally prescribed following formation of a medically significant clot. Thrombelastography is more commonly being used to diagnose hypercoagulability and monitor anti-platelet therapy.


Critics of the diagnosis complain that case evidence is spotty and lacking controlled clinical studies.[11]


  1. Mammen EF (1999). "Sticky platelet syndrome". Semin. Thromb. Hemost. 25 (4): 361–5. PMID 10548069. doi:10.1055/s-2007-994939. 
  2. Frenkel EP, Mammen EF (February 2003). "Sticky platelet syndrome and thrombocythemia". Hematol. Oncol. Clin. North Am. 17 (1): 63–83. PMID 12627663. doi:10.1016/S0889-8588(02)00096-5. 
  3. Mears KA, Van Stavern GP (July 2008). "Bilateral Simultaneous Anterior Ischaemic Optic Neuropathy Associated with Sticky Platelet Syndrome". Br J Ophthalmol 93 (7): 885–6, 913. PMID 18662911. doi:10.1136/bjo.2008.142919. 
  4. Mammen EF, Barnhart MI, Selik NR, Gilroy J, Klepach GL (1988). ""Sticky platelet syndrome": a congenital platelet abnormality predisposing to thrombosis?". Folia Haematol. Int. Mag. Klin. Morphol. Blutforsch. 115 (3): 361–5. PMID 2465231. 
  5. Mühlfeld AS, Ketteler M, Schwamborn K et al. (July 2007). "Sticky platelet syndrome: an underrecognized cause of graft dysfunction and thromboembolic complications in renal transplant recipients". Am. J. Transplant. 7 (7): 1865–8. PMID 17532753. doi:10.1111/j.1600-6143.2007.01835.x. 
  6. Bick, Rodger L (2006). Hematological complications in obstetrics, pregnancy, and gynecology. Cambridge, UK: Cambridge University Press. p. 147. ISBN 0-521-83953-X. 
  7. McKay, Robert; David R. Gambling (2008). Obstetric anesthesia and uncommon disorders. Cambridge, UK: Cambridge University Press. p. 308. ISBN 0-521-87082-8. 
  8. Chaturvedi S, Dzieczkowski JS (1999). "Protein S deficiency, activated protein C resistance and sticky platelet syndrome in a young woman with bilateral strokes". Cerebrovasc. Dis. 9 (2): 127–30. PMID 9973658. doi:10.1159/000015911. 
  10. Mammen EF (1999). "Sticky platelet syndrome". Semin. Thromb. Hemost. 25 (4): 361–5. PMID 10548069. doi:10.1055/s-2007-994939. 

See also

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