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Open Access Articles- Top Results for Sultopride

Sultopride

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Sultopride
File:Sultopride structure.svg
Systematic (IUPAC) name
N-[(1-ethylpyrrolidin-2-yl)methyl]-5-ethylsulfonyl-2-methoxy-benzamide
Clinical data
AHFS/Drugs.com International Drug Names
  • (Prescription only)
Oral, IM
Pharmacokinetic data
Half-life 3–5 hours
Identifiers
53583-79-2 7pxN
N05AL02
PubChem CID 5357
ChemSpider 5164 7pxY
UNII AA0G3TW31W 7pxY
KEGG D08549 7pxY
ChEMBL CHEMBL277945 7pxY
Chemical data
Formula C17H26N2O4S
354.46 g/mol
 14pxN (what is this?)  (verify)

Sultopride (Barnetil, Barnotil, Topral) is an atypical antipsychotic of the benzamide chemical class used in Europe, Japan, and Hong Kong for the treatment of schizophrenia.[1][2][3] It was launched by Sanofi-Aventis in 1976.[1] Sultopride acts as a selective D2 and D3 receptor antagonist.[4] It has also been shown to have clinically relevant affinity for the GHB receptor as well, a property it shares in common with amisulpride and sulpiride.[5]

References

  1. ^ a b José Miguel Vela; Helmut Buschmann; Jörg Holenz; Antonio Párraga; Antoni Torrens (2007). Antidepressants, Antipsychotics, Anxiolytics: From Chemistry and Pharmacology to Clinical Application. Weinheim: Wiley-VCH. ISBN 3-527-31058-4. 
  2. ^ Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. ISBN 3-88763-075-0. 
  3. ^ European Drug Index, 4th Edition. Boca Raton: CRC Press. 1998. ISBN 3-7692-2114-1. 
  4. ^ Burstein, E. S.; Ma, J; Wong, S; Gao, Y; Pham, E; Knapp, AE; Nash, NR; Olsson, R; Davis, RE (2005). "Intrinsic efficacy of antipsychotics at human D2, D3, and D4 dopamine receptors: identification of the clozapine metabolite N-desmethylclozapine as a D2/D3 partial agonist". The Journal of Pharmacology and Experimental Therapeutics 315 (3): 1278–87. PMID 16135699. doi:10.1124/jpet.105.092155. 
  5. ^ Maitre M, Ratomponirina C, Gobaille S, Hodé Y, Hechler V (1994). "Displacement of [3H] gamma-hydroxybutyrate binding by benzamide neuroleptics and prochlorperazine but not by other antipsychotics". Eur J Pharmacol. 256 (2): 211–4. PMID 7914168. doi:10.1016/0014-2999(94)90248-8. 



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