Surface-assisted laser desorption/ionization

Surface-assisted laser desorption/ionization (SALDI) is a soft laser desorption technique used for analyzing biomolecules by mass spectrometry.[1][2] In its first embodiment, it used graphite matrix.[1] At present, laser desorption/ionization methods using other inorganic matrices, such as nanomaterials, are often regarded as SALDI variants. A related method named "ambient SALDI" - which is a combination of conventional SALDI with ambient mass spectrometry incorporating the DART ion source - has also been demonstrated.[3]

See also


  1. ^ a b Sunner, Jan.; Dratz, Edward.; Chen, Yu-Chie. (1995). "Graphite surface-assisted laser desorption/ionization time-of-flight mass spectrometry of peptides and proteins from liquid solutions". Analytical Chemistry 67 (23): 4335–4342. ISSN 0003-2700. PMID 8633776. doi:10.1021/ac00119a021. 
  2. ^ Dattelbaum, Andrew M; Iyer, Srinivas (2006). "Surface-assisted laser desorption/ionization mass spectrometry". Expert Review of Proteomics 3 (1): 153–161. ISSN 1478-9450. PMID 16445359. doi:10.1586/14789450.3.1.153. 
  3. ^ Zhang, Jialing; Li, Ze; Zhang, Chengsen; Feng, Baosheng; Zhou, Zhigui; Bai, Yu; Liu, Huwei (2012). "Graphite-Coated Paper as Substrate for High Sensitivity Analysis in Ambient Surface-Assisted Laser Desorption/Ionization Mass Spectrometry". Analytical Chemistry 84 (7): 3296–3301. ISSN 0003-2700. PMID 22380704. doi:10.1021/ac300002g. 

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