Open Access Articles- Top Results for Suriclone


Systematic (IUPAC) name
[6-(7-chloro- 1,8-naphthyridin-2-yl)- 5-oxo- 3,7-dihydro- 2H-[1,4]dithiino[2,3-c]pyrrol- 7-yl]4-methylpiperazine- 1-carboxylate
Clinical data
53813-83-5 7pxN
PubChem CID 40903
ChemSpider 37353 7pxY
Chemical data
Formula C20H20ClN5O3S2
477.988 g/mol
 14pxN (what is this?)  (verify)

Suriclone (Suril) is a sedative and anxiolytic drug in the cyclopyrrolone family of drugs. Other cyclopyrrolone drugs include zopiclone and pagoclone.

Suriclone has a very similar pharmacological profile to the benzodiazepine family of drugs including sedative and anxiolytic properties but with less amnestic effects,[1][2] and its chemical structure is quite different from that of the benzodiazepine drugs.

The mechanism of action by which suriclone produces its sedative and anxiolytic effects is by modulating GABAA receptors, although suriclone is more subtype-selective than most benzodiazepines.[3]


  1. ^ Gilburt SJ, Fairweather DB, Kerr JS, Hindmarch I. The effects of acute and repeated doses of suriclone on subjective sleep, psychomotor performance and cognitive function in young and elderly volunteers. Fundamental and Clinical Pharmacology. 1992;6(6):251-8.
  2. ^ Saletu B, Grunberger J, Linzmayer L, Semlitsch HV, Anderer P, Chwatal K. Pharmacokinetic and -dynamic studies with a new anxiolytic, suriclone, utilizing EEG mapping and psychometry. British Journal of Clinical Pharmacology. 1994 Feb;37(2):145-56.
  3. ^ Blanchard JC; Julou L. (March 1983). "Suriclone: a new cyclopyrrolone derivative recognizing receptors labeled by benzodiazepines in rat hippocampus and cerebellum.". J Neurochem. 40 (3): 601–7. PMID 6298365. doi:10.1111/j.1471-4159.1983.tb08023.x.