Suritozole

Suritozole
	200px
Systematic (IUPAC) name
	5-(3-fluorophenyl)-2,4-dimethyl-2,4-dihydro-3H-1,2,4-triazole-3-thione
Clinical data
Identifiers
CAS Registry Number	110623-33-1 7px
ATC code	None
PubChem	CID 25431
ChemSpider	23743 7px
UNII	3H7H68317X 7px
KEGG	D05980 7px
Chemical data
Formula	C10H10FN3S
Molecular mass	223.269 g/mol
	SMILES Cn1c(=S)n(C)nc1-c2cccc(F)c2;
	InChI InChI=1S/C10H10FN3S/c1-13-9(12-14(2)10(13)15)7-4-3-5-8(11)6-7/h3-6H,1-2H3 7px ; Key:IWDUZEHNLHFBRZ-UHFFFAOYSA-N 7px ;
14px (what is this?) (verify)

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Suritozole (MDL 26,479) is an investigational cognition enhancer. It acts as a partial inverse agonist at the benzodiazepine receptor site on the GABA_A ion channel complex, but does not have either anxiogenic or convulsant effects, unlike other BZD inverse agonists such as DMCM.^[1] It was investigated for the treatment of depression and Alzheimer's disease,^[2] but clinical development seems to have been discontinued.

References

^ Miller JA, Dudley MW, Kehne JH, Sorensen SM, Kane JM (September 1992). "MDL 26,479: a potential cognition enhancer with benzodiazepine inverse agonist-like properties". Br. J. Pharmacol. 107 (1): 78–86. PMC 1907590. PMID 1330168. doi:10.1111/j.1476-5381.1992.tb14466.x.
^ Robbins DK, Hutcheson SJ, Miller TD, Green VI, Bhargava VO, Weir SJ (May 1997). "Pharmacokinetics of MDL 26479, a novel benzodiazepine inverse agonist, in normal volunteers". Biopharm Drug Dispos 18 (4): 325–34. PMID 9158880. doi:10.1002/(SICI)1099-081X(199705)18:4<325::AID-BDD21>3.0.CO;2-1.

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