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Open Access Articles- Top Results for TAAR6

TAAR6

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Identifiers
SymbolsTAAR6 ; TA4; TAR4; TAR6; TRAR4; taR-4; taR-6
External IDsOMIM608923 MGI2685074 HomoloGene27874 IUPHAR: 171 GeneCards: TAAR6 Gene
RNA expression pattern
File:PBB GE TAAR6 gnf1h10296 s at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez319100215855
EnsemblENSG00000146383ENSMUSG00000045111
UniProtQ96RI8Q5QD13
RefSeq (mRNA)NM_175067NM_001010828
RefSeq (protein)NP_778237NP_001010828
Location (UCSC)Chr 6:
132.89 – 132.89 Mb
Chr 10:
23.98 – 23.99 Mb
PubMed search[1][2]

Trace amine associated receptor 6, also known as TAAR6, is a protein which in humans is encoded by the TAAR6 gene.[1][2]

Function

TAAR6 belongs to the trace amine-associated receptor family. Trace amines are endogenous amine compounds that are chemically similar to classic biogenic amines like dopamine, norepinephrine, serotonin, and histamine. Trace amines were thought to be 'false transmitters' that displace classic biogenic amines from their storage and act on transporters in a fashion similar to the amphetamines, but the identification of brain receptors specific to trace amines indicates that they also have effects of their own.[3][4]

References

  1. ^ Borowsky B, Adham N, Jones KA, Raddatz R, Artymyshyn R, Ogozalek KL, Durkin MM, Lakhlani PP, Bonini JA, Pathirana S, Boyle N, Pu X, Kouranova E, Lichtblau H, Ochoa FY, Branchek TA, Gerald C (July 2001). "Trace amines: identification of a family of mammalian G protein-coupled receptors". Proc. Natl. Acad. Sci. U.S.A. 98 (16): 8966–71. PMC 55357. PMID 11459929. doi:10.1073/pnas.151105198. 
  2. ^ Lindemann L, Ebeling M, Kratochwil NA, Bunzow JR, Grandy DK, Hoener MC (March 2005). "Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors". Genomics 85 (3): 372–85. PMID 15718104. doi:10.1016/j.ygeno.2004.11.010. 
  3. ^ Duan J, Martinez M, Sanders AR, Hou C, Saitou N, Kitano T, Mowry BJ, Crowe RR, Silverman JM, Levinson DF, Gejman PV (October 2004). "Polymorphisms in the trace amine receptor 4 (TRAR4) gene on chromosome 6q23.2 are associated with susceptibility to schizophrenia". Am. J. Hum. Genet. 75 (4): 624–38. PMC 1182049. PMID 15329799. doi:10.1086/424887. 
  4. ^ "Entrez Gene: TAAR6 trace amine associated receptor 6". 

Further reading

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