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TAS2R10

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Identifiers
SymbolsTAS2R10 ; T2R10; TRB2
External IDsOMIM604791 MGI2681207 HomoloGene128355 IUPHAR: 666 GeneCards: TAS2R10 Gene
RNA expression pattern
File:PBB GE TAS2R10 221397 at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez50839387346
EnsemblENSG00000121318ENSMUSG00000063478
UniProtQ9NYW0Q7M722
RefSeq (mRNA)NM_023921NM_207019
RefSeq (protein)NP_076410NP_996902
Location (UCSC)Chr 12:
10.98 – 10.98 Mb
Chr 6:
131.69 – 131.69 Mb
PubMed search[1][2]

Taste receptor type 2 member 10 is a protein that in humans is encoded by the TAS2R10 gene.[1][2][3]

Function

This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13.[3]

TAS2R10 is also expressed in the smooth muscle of human airways, along with several other bitter taste receptors. Their activation in these cells causes an increase in intracellular calcium ion, which in turn triggers the opening of potassium channels which hyperpolarize the membrane and cause the smooth muscle to relax. Hence, activation of these receptors leads to bronchodilation.[4]

See also

References

  1. ^ Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJ, Zuker CS (Apr 2000). "A novel family of mammalian taste receptors". Cell 100 (6): 693–702. PMID 10761934. doi:10.1016/S0092-8674(00)80705-9. 
  2. ^ Matsunami H, Montmayeur JP, Buck LB (Apr 2000). "A family of candidate taste receptors in human and mouse". Nature 404 (6778): 601–4. PMID 10766242. doi:10.1038/35007072. 
  3. ^ a b "Entrez Gene: TAS2R10 taste receptor, type 2, member 10". 
  4. ^ Deshpande DA, Wang WC, McIlmoyle EL, Robinett KS, Schillinger RM, An SS, Sham JS, Liggett SB (November 2010). "Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction". Nat. Med. 16 (11): 1299–304. PMC 3066567. PMID 20972434. doi:10.1038/nm.2237. 

Further reading

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