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TBX21

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Identifiers
SymbolsTBX21 ; T-PET; T-bet; TBET; TBLYM
External IDsOMIM604895 MGI1888984 HomoloGene8353 GeneCards: TBX21 Gene
RNA expression pattern
File:PBB GE TBX21 220684 at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez3000957765
EnsemblENSG00000073861ENSMUSG00000001444
UniProtQ9UL17Q9JKD8
RefSeq (mRNA)NM_013351NM_019507
RefSeq (protein)NP_037483NP_062380
Location (UCSC)Chr 17:
47.73 – 47.75 Mb
Chr 11:
97.1 – 97.12 Mb
PubMed search[1][2]

T-box transcription factor TBX21 is a protein that in humans is encoded by the TBX21 gene.[1]

This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells.[1]

References

Further reading

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External links

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