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Open Access Articles- Top Results for TC-1827

TC-1827

TC-1827
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IUPAC name
(S)-N-Methyl-5-(5-pyrimidinyl)-4-penten-2-amine
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547741-76-4 7pxY
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C10H15N3
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Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

TC-1827 is an orally active, selective agonist of the α4β2 nicotinic receptors. Administration of TC-1827 improved memory and learning in a variety in rodents, and increased long-term potentiation in hippocampal slices. In addition, the compound was without significant cardiovascular side effects, except for a small, transient rise in arterial blood pressure. The pro-cognitive effects of TC-1827 last much longer than the short half life (0.2 - 1.0 hours) would suggest.[1]

References

  1. ^ Bohme, Georg Andrees (May 2004). "In vitro and in vivo characterization of TC-1827, a novel brain α4β2 nicotinic receptor agonist with pro-cognitive activity". Drug Development Research 62 (1): 26–40. doi:10.1002/ddr.10352. 


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