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Open Access Articles- Top Results for TEAD2

TEAD2

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Identifiers
SymbolsTEAD2 ; ETF; TEAD-2; TEF-4; TEF4
External IDsOMIM601729 MGI104904 HomoloGene19662 GeneCards: TEAD2 Gene
Orthologs
SpeciesHumanMouse
Entrez846321677
EnsemblENSG00000074219ENSMUSG00000030796
UniProtQ15562P48301
RefSeq (mRNA)NM_001256658NM_011565
RefSeq (protein)NP_001243587NP_035695
Location (UCSC)Chr 19:
49.84 – 49.87 Mb
Chr 7:
45.22 – 45.23 Mb
PubMed search[1][2]

Transcriptional enhancer factor TEF-4 also known as TEA domain family member 2 (TEAD-2) is a protein that in humans is encoded by the TEAD2 gene.[1][2] TEAD-2 is a transcription factor.

Clinical significance

Recent animal models indicating a possible association of TEAD2 with anencephaly.[3]

References

  1. ^ Jacquemin P, Hwang JJ, Martial JA, Dollé P, Davidson I (September 1996). "A novel family of developmentally regulated mammalian transcription factors containing the TEA/ATTS DNA binding domain". J. Biol. Chem. 271 (36): 21775–85. PMID 8702974. doi:10.1074/jbc.271.36.21775. 
  2. ^ Jacquemin P, Depetris D, Mattei MG, Martial JA, Davidson I (January 1999). "Localization of human transcription factor TEF-4 and TEF-5 (TEAD2, TEAD3) genes to chromosomes 19q13.3 and 6p21.2 using fluorescence in situ hybridization and radiation hybrid analysis". Genomics 55 (1): 127–9. PMID 9889009. doi:10.1006/geno.1998.5628. 
  3. ^ Kaneko KJ, Kohn MJ, Liu C, Depamphilis ML (2007). "Transcription factor TEAD2 is involved in neural tube closure". Genesis 45 (9): 577–87. PMC 2765819. PMID 17868131. doi:10.1002/dvg.20330. 

Further reading

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External links

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