Open Access Articles- Top Results for TEAD4


SymbolsTEAD4 ; EFTR-2; RTEF1; TCF13L1; TEF-3; TEF3; TEFR-1; hRTEF-1B
External IDsOMIM601714 MGI106907 HomoloGene74463 GeneCards: TEAD4 Gene
RNA expression pattern
File:PBB GE TEAD4 41037 at tn.png
File:PBB GE TEAD4 204281 at tn.png
More reference expression data
RefSeq (mRNA)NM_003213NM_001080979
RefSeq (protein)NP_003204NP_001074448
Location (UCSC)Chr 12:
3.07 – 3.15 Mb
Chr 6:
128.22 – 128.3 Mb
PubMed search[1][2]

Transcriptional enhancer factor TEF-3 is a protein that in humans is encoded by the TEAD4 gene.[1][2][3]

This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is preferentially expressed in the skeletal muscle, and binds to the M-CAT regulatory element found in promoters of muscle-specific genes to direct their gene expression. Alternatively spliced transcripts encoding distinct isoforms, some of which are translated through the use of a non-AUG (UUG) initiation codon, have been described for this gene.[3]


  1. ^ Jacquemin P, Depetris D, Mattei MG, Martial JA, Davidson I (Mar 1999). "Localization of human transcription factor TEF-4 and TEF-5 (TEAD2, TEAD3) genes to chromosomes 19q13.3 and 6p21.2 using fluorescence in situ hybridization and radiation hybrid analysis". Genomics 55 (1): 127–9. PMID 9889009. doi:10.1006/geno.1998.5628. 
  2. ^ Stewart AF, Richard CW 3rd, Suzow J, Stephan D, Weremowicz S, Morton CC, Adra CN (Feb 1997). "Cloning of human RTEF-1, a transcriptional enhancer factor-1-related gene preferentially expressed in skeletal muscle: evidence for an ancient multigene family". Genomics 37 (1): 68–76. PMID 8921372. doi:10.1006/geno.1996.0522. 
  3. ^ a b "Entrez Gene: TEAD4 TEA domain family member 4". 

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