Adverts

Open Access Articles- Top Results for TLR10

TLR10

Template:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/row
Identifiers
SymbolsTLR10 ; CD290
External IDsOMIM606270 HomoloGene12809 IUPHAR: 1760 GeneCards: TLR10 Gene
Orthologs
SpeciesHumanMouse
Entrez81793n/a
EnsemblENSG00000174123n/a
UniProtQ9BXR5n/a
RefSeq (mRNA)NM_001017388n/a
RefSeq (protein)NP_001017388n/a
Location (UCSC)Chr 4:
38.77 – 38.78 Mb
n/a
PubMed search[1]n/a

Toll-like receptor 10 is a protein that in humans is encoded by the TLR10 gene.[1] TLR10 has also been designated as CD290 (cluster of differentiation 290).

Function

The protein encoded by this gene is a member of the toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is most highly expressed in lymphoid tissues such as spleen, lymph node, thymus, and tonsil. Its exact function is not known. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.[2]

References

  1. ^ Chuang T, Ulevitch RJ (Mar 2001). "Identification of hTLR10: a novel human Toll-like receptor preferentially expressed in immune cells". Biochim Biophys Acta 1518 (1-2): 157–61. PMID 11267672. doi:10.1016/s0167-4781(00)00289-x. 
  2. ^ "Entrez Gene: TLR10 toll-like receptor 10". 

Further reading

</dl>

External links


Lua error in package.lua at line 80: module 'Module:Buffer' not found.