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TNFRSF19

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Identifiers
SymbolsTNFRSF19 ; TAJ; TAJ-alpha; TRADE; TROY
External IDsOMIM606122 MGI1352474 HomoloGene8481 IUPHAR: 1891 GeneCards: TNFRSF19 Gene
Orthologs
SpeciesHumanMouse
Entrez5550429820
EnsemblENSG00000127863ENSMUSG00000060548
UniProtQ9NS68Q9JLL3
RefSeq (mRNA)NM_001204458NM_001164155
RefSeq (protein)NP_001191387NP_001157627
Location (UCSC)Chr 13:
24.14 – 24.25 Mb
Chr 14:
60.96 – 61.05 Mb
PubMed search[1][2]

Tumor necrosis factor receptor superfamily, member 19, also known as TNFRSF19 and TROY is a human gene.[1]

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is highly expressed during embryonic development. It has been shown to interact with TRAF family members, and to activate JNK signaling pathway when overexpressed in cells. This receptor is capable of inducing apoptosis by a caspase-independent mechanism, and it is thought to play an essential role in embryonic development. Alternatively spliced transcript variants encoding distinct isoforms have been described.[1]

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