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Open Access Articles- Top Results for TNNC2

TNNC2

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Identifiers
SymbolTNNC2
External IDsOMIM191039 MGI98780 HomoloGene55727 GeneCards: TNNC2 Gene
RNA expression pattern
File:PBB GE TNNC2 205388 at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez712521925
EnsemblENSG00000101470ENSMUSG00000017300
UniProtP02585P20801
RefSeq (mRNA)NM_003279NM_009394
RefSeq (protein)NP_003270NP_033420
Location (UCSC)Chr 20:
44.45 – 44.46 Mb
Chr 2:
164.78 – 164.78 Mb
PubMed search[1][2]

Troponin C, skeletal muscle is a protein that in humans is encoded by the TNNC2 gene.[1][2]

Troponin (Tn), a key protein complex in the regulation of striated muscle contraction, is composed of 3 subunits. The Tn-I subunit inhibits actomyosin ATPase, the Tn-T subunit binds tropomyosin and Tn-C, while the Tn-C subunit binds calcium and overcomes the inhibitory action of the troponin complex on actin filaments. The protein encoded by this gene is the Tn-C subunit.[2]

References

  1. ^ Gahlmann R, Kedes L (Aug 1990). "Cloning, structural analysis, and expression of the human fast twitch skeletal muscle troponin C gene". J Biol Chem 265 (21): 12520–8. PMID 2373703. 
  2. ^ a b "Entrez Gene: TNNC2 troponin C type 2 (fast)". 

Further reading

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