Open Access Articles- Top Results for Talbutal


Systematic (IUPAC) name
Clinical data
115-44-6 7pxY
PubChem CID 8275
DrugBank DB00306 7pxY
ChemSpider 7976 7pxY
UNII 4YIR8202AX 7pxY
ChEMBL CHEMBL1200802 7pxN
Synonyms 5-(1-methylpropyl)-5-(2-propenyl)-2,4,6(1H,3H,5H)-pyrimidinetrione
Chemical data
Formula C11H16N2O3
224.256 g/mol
 14pxN (what is this?)  (verify)

Talbutal (Lotusate) is a barbiturate with a short to intermediate duration of action. It is a structural isomer of butalbital. Talbutal is a schedule III drug in the U.S.


Talbutal is a short to intermediate-acting barbiturate. Barbiturates act as nonselective depressants of the central nervous system (CNS), capable of producing all levels of CNS mood alteration from excitation to mild sedation, hypnosis, and deep coma. In sufficiently high therapeutic doses, barbiturates induce anesthesia.[1]

Mechanism of action

Talbutal binds at a distinct binding site associated with a Cl ionopore at the GABAA receptor, increasing the duration of time for which the Cl ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged.


Symptoms of acute barbiturate poisoning include drowsiness, confusion, coma, respiratory depression, hypotension,[1] and shock.


  1. 1.0 1.1 Mutschler, Ernst; Schäfer-Korting, Monika (2001). Arzneimittelwirkungen (in German) (8 ed.). Stuttgart: Wissenschaftliche Verlagsgesellschaft. pp. 280ff. ISBN 3-8047-1763-2. 

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