Adverts

Open Access Articles- Top Results for Talsupram

Talsupram

</th></tr>
Talsupram
File:Talsupram.png
Systematic (IUPAC) name
3-(3,3-dimethyl-1-phenyl-2-benzothiophen-1-yl)-N-methyl-propan-1-amine
Clinical data
  • Uncontrolled
Oral
Identifiers
21489-20-3
None
PubChem CID 33014
ChemSpider 30557
UNII C6Z73MW6CR 7pxY
Chemical data
Formula C20H25NS
311.48 g/mol

Talsupram (Lu 5-005) is a selective norepinephrine reuptake inhibitor (NRI) which was investigated as an antidepressant in the 1960s and 1970s but was never marketed.[1][2][3] Along with talopram, it is structurally related to the selective serotonin reuptake inhibitor (SSRI) citalopram.[4]

See also

References

  1. ^ Pawłowski L, Mazela H (1986). "Effects of antidepressant drugs, selective noradrenaline-or 5-hydroxytryptamine uptake inhibitors, on apomorphine-induced hypothermia in mice". Psychopharmacology 88 (2): 240–6. PMID 3006113. doi:10.1007/BF00652248. 
  2. ^ McConathy J, Owens MJ, Kilts CD et al. (August 2004). "Synthesis and biological evaluation of [11C]talopram and [11C]talsupram: candidate PET ligands for the norepinephrine transporter". Nuclear Medicine and Biology 31 (6): 705–18. PMID 15246361. doi:10.1016/j.nucmedbio.2003.05.001. 
  3. ^ Kelliher P, Kelly JP, Leonard BE, Sánchez C (April 2003). "Effects of acute and chronic administration of selective monoamine re-uptake inhibitors in the rat forced swim test". Psychoneuroendocrinology 28 (3): 332–47. PMID 12573300. doi:10.1016/S0306-4530(02)00026-4. 
  4. ^ http://www.healyprozac.com/Book/Introduction.doc