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Terazosin

File:Terazosin.svg
Systematic (IUPAC) name
(RS)-6,7-dimethoxy-2-[4-(tetrahydrofuran-2-ylcarbonyl)piperazin-1-yl]quinazolin-4-amine
Clinical data
Trade names	Hytrin
AHFS/Drugs.com	monograph
MedlinePlus	a693046
Legal status	US: ℞-only
Pharmacokinetic data
Protein binding	90-94%
Half-life	12 hours
Identifiers
CAS Registry Number	63590-64-7 7pxY
ATC code	G04CA03
PubChem	CID 5401
DrugBank	DB01162 7pxY
ChemSpider	5208 7pxY
UNII	8L5014XET7 7pxY
KEGG	D08569 7pxY
ChEBI	CHEBI:9445 7pxY
ChEMBL	CHEMBL611 7pxY
Synonyms	[4-(4-amino-6,7-dimethoxy-quinazolin-2-yl)piperazin-1-yl]-tetrahydrofuran-2-yl-methanone
Chemical data
Formula	C19H25N5O4
Molecular mass	387.433 g/mol
SMILES O=C(N3CCN(c2nc1cc(OC)c(OC)cc1c(n2)N)CC3)C4OCCC4
InChI InChI=1S/C19H25N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h10-11,14H,3-9H2,1-2H3,(H2,20,21,22)  7pxY Key:VCKUSRYTPJJLNI-UHFFFAOYSA-N  7pxY
14pxY (what is this?)  (verify)

Terazosin (marketed as Hytrin or Zayasel) is a selective alpha 1 antagonist used for treatment of symptoms of an enlarged prostate (BPH). It also acts to lower the blood pressure, and is therefore a drug of choice for men with hypertension and prostate enlargement.

It works by blocking the action of adrenaline on smooth muscle of the bladder and the blood vessel walls.

Most common side effects include dizziness, drowsiness, headache, constipation, loss of appetite, fatigue, nasal congestion or dry eyes, but they generally go away after only a few days of use. Therapy should always be started with a low dose to avoid first dose phenomenon. Sexual side effects are rare, but may include priapism or erectile dysfunction.