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Terazosin
File:Terazosin.svg | |
Systematic (IUPAC) name | |
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(RS)-6,7-dimethoxy-2-[4-(tetrahydrofuran-2-ylcarbonyl)piperazin-1-yl]quinazolin-4-amine | |
Clinical data | |
Trade names | Hytrin |
AHFS/Drugs.com | monograph |
MedlinePlus | a693046 |
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Pharmacokinetic data | |
Protein binding | 90-94% |
Half-life | 12 hours |
Identifiers | |
63590-64-7 7px | |
G04CA03 | |
PubChem | CID 5401 |
DrugBank | DB01162 7px |
ChemSpider | 5208 7px |
UNII | 8L5014XET7 7px |
KEGG | D08569 7px |
ChEBI | CHEBI:9445 7px |
ChEMBL | CHEMBL611 7px |
Synonyms | [4-(4-amino-6,7-dimethoxy-quinazolin-2-yl)piperazin-1-yl]-tetrahydrofuran-2-yl-methanone |
Chemical data | |
Formula | C19H25N5O4 |
387.433 g/mol | |
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Terazosin (marketed as Hytrin or Zayasel) is a selective alpha 1 antagonist used for treatment of symptoms of an enlarged prostate (BPH). It also acts to lower the blood pressure, and is therefore a drug of choice for men with hypertension and prostate enlargement.
It works by blocking the action of adrenaline on smooth muscle of the bladder and the blood vessel walls.
Most common side effects include dizziness, drowsiness, headache, constipation, loss of appetite, fatigue, nasal congestion or dry eyes, but they generally go away after only a few days of use. Therapy should always be started with a low dose to avoid first dose phenomenon.[1] Sexual side effects are rare, but may include priapism or erectile dysfunction.
References
- ^ Hytrin (Terazosin Hcl) drug warnings and precautions - prescription drugs and medications at RxList
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