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Terazosin

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Terazosin
File:Terazosin.svg
Systematic (IUPAC) name
(RS)-6,7-dimethoxy-2-[4-(tetrahydrofuran-2-ylcarbonyl)piperazin-1-yl]quinazolin-4-amine
Clinical data
Trade names Hytrin
AHFS/Drugs.com monograph
MedlinePlus a693046
Pharmacokinetic data
Protein binding 90-94%
Half-life 12 hours
Identifiers
63590-64-7 7pxY
G04CA03
PubChem CID 5401
DrugBank DB01162 7pxY
ChemSpider 5208 7pxY
UNII 8L5014XET7 7pxY
KEGG D08569 7pxY
ChEBI CHEBI:9445 7pxY
ChEMBL CHEMBL611 7pxY
Synonyms [4-(4-amino-6,7-dimethoxy-quinazolin-2-yl)piperazin-1-yl]-tetrahydrofuran-2-yl-methanone
Chemical data
Formula C19H25N5O4
387.433 g/mol
 14pxY (what is this?)  (verify)

Terazosin (marketed as Hytrin or Zayasel) is a selective alpha 1 antagonist used for treatment of symptoms of an enlarged prostate (BPH). It also acts to lower the blood pressure, and is therefore a drug of choice for men with hypertension and prostate enlargement.

It works by blocking the action of adrenaline on smooth muscle of the bladder and the blood vessel walls.

Most common side effects include dizziness, drowsiness, headache, constipation, loss of appetite, fatigue, nasal congestion or dry eyes, but they generally go away after only a few days of use. Therapy should always be started with a low dose to avoid first dose phenomenon.[1] Sexual side effects are rare, but may include priapism or erectile dysfunction.

References

  1. ^ Hytrin (Terazosin Hcl) drug warnings and precautions - prescription drugs and medications at RxList

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