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Tetrazolylglycine

Tetrazolylglycine
1 : 1 mixture (racemate)
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IUPAC name
(RS)-amino(1H-tetrazol-5-yl)acetic acid
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138199-51-6
ChEMBL ChEMBL140784 7pxY
ChemSpider 112321 7pxY
Jmol-3D images Image
PubChem Template:Chembox PubChem/format
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C3H5N5O2
Molar mass 143.104
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
 14pxY verify (what is10pxY/10pxN?)
Infobox references

Tetrazolylglycine (Tet-Gly, LY-285,265) is a potent and selective NMDA receptor agonist, stimulating the NMDA receptor with higher potency than either glutamate or NMDA.[1] It is a potent convulsant and excitotoxin and is used in scientific research.[2][3]

References

  1. ^ Lunn WH, Schoepp DD, Calligaro DO, Vasileff RT, Heinz LJ, Salhoff CR, O'Malley PJ. DL-tetrazol-5-ylglycine, a highly potent NMDA agonist: its synthesis and NMDA receptor efficacy. Journal of Medicinal Chemistry. 1992 Nov 27;35(24):4608-12. PMID 1361579
  2. ^ Schoepp DD, Smith CL, Lodge D, Millar JD, Leander JD, Sacaan AI, Lunn WH. D,L-(tetrazol-5-yl) glycine: a novel and highly potent NMDA receptor agonist. European Journal of Pharmacology. 1991 Oct 15;203(2):237-43. PMID 1686860
  3. ^ Schoepp DD, Lunn WH, Salhoff CR, McDonald JW. The NMDA receptor agonist DL-(tetrazol-5-yl)glycine is a highly potent excitotoxin. European Journal of Pharmacology. 1994 Jan 3;270(1):67-72. PMID 8157082

Template:Glutamate receptor ligands


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