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Thialbarbital

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Thialbarbital
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Systematic (IUPAC) name
5-allyl-5-cyclohex-2-en-1-yl-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
Clinical data
Identifiers
3546-29-0 7pxN
None
PubChem CID 3032306
ChemSpider 2297316 7pxY
UNII ENV72C33QD 7pxY
ChEMBL CHEMBL2104657 7pxN
Synonyms Kemithal, 5-(1-cyclohex-2-enyl)-5-prop-2-enyl-2-sulfanylidene-1,3-diazinane-4,6-dione
Chemical data
Formula C13H16N2O2S
264.344 g/mol
 14pxN (what is this?)  (verify)

Thialbarbital (Intranarcon) is a barbiturate derivative invented in the 1960s. It has sedative effects, and was used primarily for induction in surgical anaesthesia. [1] Thialbarbital is short acting and has less of a tendency to induce respiratory depression than other barbiturate derivatives such as pentobarbital. [2]

Synthesis

File:Thialbarbital synthesis.svg
Thialbarbital synthesis: Volwiler, Tabern, U.S. Patent 2,153,730 (1939 to Abbott).

See also

References

  1. Golovchinsky VB, Plehotkina SI. Difference in the sensitivity of the cerebral cortex and midbrain reticular formation to the action of diethylether and thialbarbital. Brain Research. 1971 Jul 9;30(1):37-47.
  2. Bercovitz AB, Godke RA, Biellier HV, Short CE. Surgical anesthesia in turkeys with thialbarbital sodium. American Journal of Veterinary Research. 1975 Mar;36(3):301-2.



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