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Thiamylal

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Thiamylal
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Systematic (IUPAC) name
5-allyl-5-(1-methylbutyl)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
Clinical data
AHFS/Drugs.com International Drug Names
Pharmacokinetic data
Metabolism Hepatic
Half-life 14.3 h (cats)
Identifiers
77-27-0 7pxY
QN01AF90
PubChem CID 3032285
DrugBank DB01154 7pxY
ChemSpider 2297298 7pxY
UNII 01T23W89FR 7pxY
KEGG D06106 7pxY
ChEBI CHEBI:9536 7pxY
ChEMBL CHEMBL440 7pxY
Synonyms Thiamylal, Thioseconal, Surital
Chemical data
Formula C12H18N2O2S
254.35 g/mol
 14pxY (what is this?)  (verify)

Thiamylal (Surital) is a barbiturate derivative invented in the 1950s. It has sedative, anticonvulsant, and hypnotic effects, and is used as a strong but short acting sedative. Thiamylal is still in current use, primarily for induction in surgical anaesthesia [1] or as an anticonvulsant to counteract side effects from other anaesthetics.[2] It is the thiobarbiturate analogue of secobarbital.

Synthesis

File:Thiamylal synthesis.svg
Thiamylal synthesis: GB 613704  (1948 to Lilly);[3] Donnison, U.S. Patent 2,876,225 (1959 to Abbott).

References

  1. ^ Hsieh MY, Hung GY, Hsieh YL, Chang CY, Hwang B. Deep sedation with methohexital or thiamylal with midazolam for invasive procedures in children with acute lymphoblastic leukemia. Acta Paediatrica Taiwan. 2005 Sep-Oct;46(5):294-300.
  2. ^ Tsai CJ, Wang HM, Lu IC, Tai CF, Wang LF, Soo LY, Lu DV. Seizure after local anesthesia for nasopharyngeal angiofibroma. Kaohsiung Journal of Medical Sciences. 2007 Feb;23(2):97-100.
  3. ^ Abe et al., J. Pharm. Soc. Jpn. 75, 891 (1955).



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