Adverts

Open Access Articles- Top Results for Thioperamide

Thioperamide

</th></tr>
Thioperamide
File:Thioperamide.svg
Systematic (IUPAC) name
N-Cyclohexyl-4-(1H-imidazol-4-yl)piperidine-1-carbothioamide
Clinical data
Identifiers
106243-16-7 7pxN
None
PubChem CID 3035905
IUPHAR ligand 1267
ChemSpider 2300031 7pxY
ChEMBL CHEMBL260374 7pxY
Chemical data
Formula C15H24N4S
292.44 g/mol
 14pxN (what is this?)  (verify)

Thioperamide is a potent HRH4 antagonist and selective HRH3 antagonist capable of crossing the blood–brain barrier.[1] It was used by Jean-Charles Schwartz in his early experiments regarding the H3 receptor.[2] Thioperamide was found to be an antagonist of histamine autoreceptors, which negatively regulate the release of histamine, and enhances the activity of histaminergic neurons by blocking autoreceptors, leading to greater release of histamine.

See also

References

  1. ^ "IUPHAR Database | Ligand Summary | thioperamide". 
  2. ^ Schwartz, Jean-Charles. The histamine H3 receptor: from discovery to clinical trials with pitolisant. BPJ 2011 May [1]


Lua error in package.lua at line 80: module 'Module:Buffer' not found.