Adverts

Open Access Articles- Top Results for Thiothixene

Thiothixene

</th></tr></th></tr>
Thiothixene
220px
Systematic (IUPAC) name
(9Z)-N,N-dimethyl-9-[3-(4-methylpiperazin-1-yl)propylidene]-9H-thioxanthene-2-sulfonamide
Clinical data
Trade names Navane
AHFS/Drugs.com monograph
MedlinePlus a682867
  • (Prescription only)
Oral
Pharmacokinetic data
Metabolism Hepatic
Half-life 10-20 hours
Identifiers
5591-45-7 7pxY
N05AF04
PubChem CID 941651
IUPHAR ligand 212
DrugBank DB01623 7pxY
ChemSpider 819430 7pxY
UNII 7318FJ13YJ 7pxY
ChEMBL CHEMBL1201 7pxY
Chemical data
Formula C23H29N3O2S2
443.627 g/mol
 14pxY (what is this?)  (verify)

Tiotixene (INN) or Thiothixene (USAN; Navane) is a typical antipsychotic drug of the thioxanthene class used in the treatment of psychoses like schizophrenia. It was introduced on July 24, 1967[1] by Pfizer.[2]

Thiothixene is the only first generation typical thioxanthene antipsychotic approved for use in the United States.

Chemistry

500px

See also:

  • J.F. Muren, B.M. Bloom, DE 1470157  (1963).
  • Chas. Pfizer & Co., BE 647066  (1964).
  • Muren, James F.; Bloom, Barry M. (1970). "Thioxanthene psychopharmacological agents. II. 9-(3-aminopropylidene)-N,N-dimethylthioxanthene-2-sulfonamides". Journal of Medicinal Chemistry 13 (1): 17–23. PMID 5412109. doi:10.1021/jm00295a005.  edit

See also

References

  1. ^ http://www.accessdata.fda.gov/scripts/cder/drugsatfda/index.cfm
  2. ^ José Miguel Vela; Helmut Buschmann; Jörg Holenz; Antonio Párraga; Antoni Torrens (2007). Antidepressants, Antipsychotics, Anxiolytics: From Chemistry and Pharmacology to Clinical Application. Weinheim: Wiley-VCH. p. 520. ISBN 3-527-31058-4. 

Template:Navbox with collapsible sections


Lua error in package.lua at line 80: module 'Module:Buffer' not found.