Frequent Links
Thiothixene
220px | |
Systematic (IUPAC) name | |
---|---|
(9Z)-N,N-dimethyl-9-[3-(4-methylpiperazin-1-yl)propylidene]-9H-thioxanthene-2-sulfonamide | |
Clinical data | |
Trade names | Navane |
AHFS/Drugs.com | monograph |
MedlinePlus | a682867 |
| |
Oral | |
Pharmacokinetic data | |
Metabolism | Hepatic |
Half-life | 10-20 hours |
Identifiers | |
5591-45-7 7px | |
N05AF04 | |
PubChem | CID 941651 |
IUPHAR ligand | 212 |
DrugBank | DB01623 7px |
ChemSpider | 819430 7px |
UNII | 7318FJ13YJ 7px |
ChEMBL | CHEMBL1201 7px |
Chemical data | |
Formula | C23H29N3O2S2 |
443.627 g/mol | |
| |
14px (what is this?) (verify) |
Tiotixene (INN) or Thiothixene (USAN; Navane) is a typical antipsychotic drug of the thioxanthene class used in the treatment of psychoses like schizophrenia. It was introduced on July 24, 1967[1] by Pfizer.[2]
Thiothixene is the only first generation typical thioxanthene antipsychotic approved for use in the United States.
Chemistry
- Bloom, B. M.; Muren, J. F.; 1967, U.S. Patent 3,310,553
See also:
- J.F. Muren, B.M. Bloom, DE 1470157 (1963).
- Chas. Pfizer & Co., BE 647066 (1964).
- Muren, James F.; Bloom, Barry M. (1970). "Thioxanthene psychopharmacological agents. II. 9-(3-aminopropylidene)-N,N-dimethylthioxanthene-2-sulfonamides". Journal of Medicinal Chemistry 13 (1): 17–23. PMID 5412109. doi:10.1021/jm00295a005.
See also
References
- ^ http://www.accessdata.fda.gov/scripts/cder/drugsatfda/index.cfm
- ^ José Miguel Vela; Helmut Buschmann; Jörg Holenz; Antonio Párraga; Antoni Torrens (2007). Antidepressants, Antipsychotics, Anxiolytics: From Chemistry and Pharmacology to Clinical Application. Weinheim: Wiley-VCH. p. 520. ISBN 3-527-31058-4.
|
Template:Navbox with collapsible sections
|
|
|
|
Lua error in package.lua at line 80: module 'Module:Buffer' not found.