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Open Access Articles- Top Results for Thozalinone

Thozalinone

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Thozalinone
200px
Systematic (IUPAC) name
(RS)-2-(dimethylamino)-5-phenyl-1,3-oxazol-4(5H)-one
Clinical data
  • (Prescription only)
Oral
Identifiers
655-05-0
None
PubChem CID 12602
ChemSpider 12082 7pxY
UNII 68X5932947 7pxY
KEGG D06115 7pxY
Chemical data
Formula C11H12N2O2
204.225 g/mol
 14pxY (what is this?)  (verify)

Thozalinone (Stimsen) is a psychostimulant that has been used as an antidepressant in Europe.[1][2][3][4] It has also been trialed as an anorectic.[5] Thozalinone likely acts via inducing the release of norepinephrine and dopamine as with its analogues pemoline and aminorex.[1][6][7]

References

  1. ^ a b Greenblatt EN, Osterberg AC (July 1965). "Some pharmacologic properties of thozalinone, a new excitant". Toxicology and Applied Pharmacology 7 (4): 566–78. PMID 4378772. doi:10.1016/0041-008X(65)90042-6. 
  2. ^ Dictionary of organic compounds. London: Chapman & Hall. 1996. ISBN 0-412-54090-8. 
  3. ^ Merck index on CD-ROM: Windows. London: Chapman & Hall EPD. 1998. ISBN 0-412-82910-X. 
  4. ^ Gallant DM, Bishop MP, Scrignar CB, Hornsby L, Moore B, Inturrisi BB (December 1966). "A double-blind study of thozalinone (C1 39,808) in depressed outpatients". Current Therapeutic Research, Clinical and Experimental 8 (12): 621–2. PMID 4962734. 
  5. ^ Leite AC, Liepen LL, Costa VP (September 1971). "[Clinical trial of Stimsem Thozalinone in the treatment of obese patients]". Revista Brasileira De Medicina (in Portuguese) 28 (9): 475–8. PMID 5139648. 
  6. ^ Yen-Koo HC, Balazs T (1980). "Detection of dopaminergic supersensitivity induced by neuroleptic drugs in mice". Drug and Chemical Toxicology 3 (2): 237–47. PMID 6112126. doi:10.3109/01480548009108286. 
  7. ^ Yen-Koo HC, Davis DA, Balazs T (1985). "Inhibition of dopaminergic agonist-induced gnawing behavior by neuroleptic drugs in mice". Drug and Chemical Toxicology 8 (6): 495–502. PMID 2868876. doi:10.3109/01480548509041072. 



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