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Tiazofurin

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Tiazofurin
File:Tiazofurin.svg
Systematic (IUPAC) name
(1R)-1-[4-(aminocarbonyl)-1,3-thiazol-2-yl]-1,4-anhydro-D-ribitol
Clinical data
Identifiers
60084-10-8
L01XX18
PubChem CID 457954
ChemSpider 403014 7pxY
UNII ULJ82834RE 7pxY
ChEMBL CHEMBL108358 7pxY
Synonyms 2-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3-thiazole-4-carboxamide
Chemical data
Formula C9H12N2O5S
260.268 g/mol
 14pxY (what is this?)  (verify)

Tiazofurin is an inhibitor of IMP dehydrogenase. Tiazofurin and its analogues are under investigation for potential use in the treatment of cancer.[1]

References

  1. Popsavin M, Torović L, Svircev M et al. (2006). "Synthesis and antiproliferative activity of two new tiazofurin analogues with 2'-amido functionalities". Bioorg. Med. Chem. Lett. 16 (10): 2773–6. PMID 16495053. doi:10.1016/j.bmcl.2006.02.001. 


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