Open Access Articles- Top Results for Tonofibril


Tonofibrils are cytoplasmic protein structures in epithelial tissues[1] that converge at desmosomes and hemidesmosomes.

Tonofilaments are also associated with desmosomes (macula adherens), anchoring them to the cytoskeleton.


They are made of keratin (a type of intermediate filament in the cytoskeleton) tonofilaments.[2] Tonofilaments are keratin intermediate filaments that make up tonofibrils in epithelial tissue. In epithelial cells, tonofilaments loop through desmosomes.

The protein filaggrin is believed to have an important role in holding them together as tonofibrils.


  1. "tonofibril" at Dorland's Medical Dictionary
  2. Yoon KH, Yoon M, Moir RD, Khuon S, Flitney FW, Goldman RD (April 2001). "Insights into the dynamic properties of keratin intermediate filaments in living epithelial cells". J. Cell Biol. 153 (3): 503–16. PMC 2190576. PMID 11331302. doi:10.1083/jcb.153.3.503. 

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