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Transient neonatal diabetes mellitus

Transient neonatal diabetes mellitus
Classification and external resources
ICD-10 P70.2
OMIM 601410 610374 610582
NCI Transient neonatal diabetes mellitus
Patient UK Transient neonatal diabetes mellitus

Transient neonatal diabetes mellitus (TNDM) is a form of diabetes mellitus presenting at birth that is not permanent. This disease is considered to be a type of maturity onset diabetes of the young (MODY).

Types include:

Type OMIM Gene Locus Description
TNDM1 601410 ZFP57, PLAGL1 6p22.1, 6p24.2
TNDM2 610374 ABCC8 11p15.1 Due to the mutations of the other subunit of the KATP channel, SUR1, which is encoded by the ABCC8 gene.[1]
TNDM3 610582 KCNJ11 11p15.1

It is to do with genetics and is often associated with having an added Chromosome 7 gene (mostly from the paternal side).[citation needed]

The form on chromosome 6 can involve imprinting.[2]


  1. ^ de Wet H, Proks P, Lafond M et al. (May 2008). "A mutation (R826W) in nucleotide-binding domain 1 of ABCC8 reduces ATPase activity and causes transient neonatal diabetes". EMBO Rep. 9 (7): 648–54. PMC 2475326. PMID 18497752. doi:10.1038/embor.2008.71. 
  2. ^ Raphaël Scharfmann (2007). Development of the Pancreas and Neonatal Diabetes. Karger Publishers. pp. 113–. ISBN 978-3-8055-8385-5. Retrieved 10 November 2010. 
  3. ^ "Other Forms (MODY, LADA, Neonatal)". Retrieved 20 November 2014. 

External links

See also

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