This page is a soft redirect.Transition]].
In genetics, a transition is a point mutation that changes a purine nucleotide to another purine (A ↔ G) or a pyrimidine nucleotide to another pyrimidine (C ↔ T). Approximately two out of three single nucleotide polymorphisms (SNPs) are transitions.
Transitions can be caused by oxidative deamination and tautomerization. Although there are twice as many possible transversions, transitions appear more often in genomes, possibly due to the molecular mechanisms that generate them.
- Collins DW, Jukes TH (April 1994). "Rates of transition and transversion in coding sequences since the human-rodent divergence". Genomics 20 (3): 386–96. PMID 8034311. doi:10.1006/geno.1994.1192.
- Mutations & Mutagenesis
- Ebersberger I, Metzler D, Schwarz C, Pääbo S (June 2002). "Genomewide comparison of DNA sequences between humans and chimpanzees". Am. J. Hum. Genet. 70 (6): 1490–7. PMC 379137. PMID 11992255. doi:10.1086/340787.
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