Open Access Articles- Top Results for Transition (genetics)

Transition (genetics)

For other uses, see [[Transition (disambiguation)#REDIRECTmw:Help:Magic words#Other
This page is a soft redirect.Transition]].
File:Transitions and transversions.svg
Definition of transitions and transversions.

In genetics, a transition is a point mutation that changes a purine nucleotide to another purine (AG) or a pyrimidine nucleotide to another pyrimidine (CT). Approximately two out of three single nucleotide polymorphisms (SNPs) are transitions.[1]

Transitions can be caused by oxidative deamination and tautomerization.[2] Although there are twice as many possible transversions, transitions appear more often in genomes, possibly due to the molecular mechanisms that generate them.[3]

5-Methylcytosine is more prone to transition than unmethylated cytosine, due to spontaneous deamination. This mechanism is important because it dictates the rarity of CpG islands.

See also


  1. ^ Collins DW, Jukes TH (April 1994). "Rates of transition and transversion in coding sequences since the human-rodent divergence". Genomics 20 (3): 386–96. PMID 8034311. doi:10.1006/geno.1994.1192. 
  2. ^ Mutations & Mutagenesis
  3. ^ Ebersberger I, Metzler D, Schwarz C, Pääbo S (June 2002). "Genomewide comparison of DNA sequences between humans and chimpanzees". Am. J. Hum. Genet. 70 (6): 1490–7. PMC 379137. PMID 11992255. doi:10.1086/340787. 

External links

Lua error in package.lua at line 80: module 'Module:Buffer' not found.