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Trifluperidol

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Trifluperidol
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Systematic (IUPAC) name
1-(4-fluorophenyl)- 4-{4-hydroxy- 4-[3-(trifluoromethyl)phenyl] piperidin-1-yl} butan-1-one
Clinical data
AHFS/Drugs.com International Drug Names
Oral
Identifiers
749-13-3 7pxN
N05AD02
PubChem CID 5567
ChemSpider 5366 7pxY
UNII R8869Q7R8I 7pxY
ChEMBL CHEMBL15023 7pxY
Chemical data
Formula C22H23F4NO2
409.417 g/mol
 14pxN (what is this?)  (verify)

Trifluperidol is a typical antipsychotic of the butyrophenone chemical class. It has general properties similar to those of haloperidol, but is considerably more potent by weight, and causes relatively more severe side effects, especially tardive dyskinesia and other extrapyramidal effects. It is used in the treatment of psychoses including mania and schizophrenia. It was discovered at Janssen Pharmaceutica in 1959.

Synthesis

File:Trifluperidol Synthesis.png
Trifluperidol Synthesis: P. Janssen, J. Adriaan, GB 895309  (1962), U.S. Patent 3,438,991 (1969).

References

  • Gallant DM, Bishop MP, Timmons E, Steele CA, A controlled evaluation of Trifluperidol: a new potent psychopharmacologic agent, Curr Ther Res Clin Exp. 1963 Sep;27:463-71.
  • Gallant DM, Bishop MP, Timmons E, Steele CA, Trifluperidol: a butyrophenone derivative, Am J Psychiatry. 1963 Nov;120:485-7.


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