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Triprolidine

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Triprolidine
File:Triprolidine.svg
Systematic (IUPAC) name
2-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-yl-
prop-1-enyl]pyridine
Clinical data
AHFS/Drugs.com monograph
  • C (US)
Oral
Pharmacokinetic data
Bioavailability 4% oral
Protein binding 90%
Metabolism Hepatic (CYP2D6)
Half-life 4-6 hours
Excretion Renal
Identifiers
486-12-4 7pxY
R06AX07
PubChem CID 5282443
IUPHAR ligand 1228
DrugBank DB00427 7pxY
ChemSpider 4445597 7pxY
UNII 2L8T9S52QM 7pxY
KEGG D01782 7pxN
ChEBI CHEBI:84116 7pxN
ChEMBL CHEMBL855 7pxY
Chemical data
Formula C19H22N2
278.391 g/mol
Physical data
Melting point Script error: No such module "convert".
500 mg/mL (20 °C)
 14pxN (what is this?)  (verify)

Triprolidine (Actidil, Myidil, Actifed[In combination with pseudoephedrine, and either dextromethorphan or guaifenesin] in addition in liquids) is an antihistamine thats often sold over-the-counter that has anticholinergic properties.[1] It is used to combat the symptoms associated with allergies and is sometimes combined with other cold medications designed to provide general relief for flu-like symptoms.[2] Like many antihistamines, the most common side effect is drowsiness.[1] Triprolidine is a quick acting drug that can clear congestion and stop runny noses in 15-30 minutes.[citation needed]

References

  1. ^ a b Goldsmith, P.; Dowd, P. M. (1993). "The new H1 antihistamines. Treatment of urticaria and other clinical problems". Dermatologic clinics 11 (1): 87–95. PMID 8094649.  edit
  2. ^ Williams, B. O.; Liao, S. H.; Lai, A. A.; Arnold, J. D.; Perkins, J. G.; Blum, M. R.; Findlay, J. W. (1984). "Bioavailability of pseudoephedrine and triprolidine from combination and single-ingredient products". Clinical pharmacy 3 (6): 638–643. PMID 6509877.  edit

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